Novel canine circovirus strains from Thailand: Evidence for genetic recombination

Abstract Canine circoviruses (CanineCV’s), belonging to the genus Circovirus of the Circoviridae family, were detected by next generation sequencing in samples from Thai dogs with respiratory symptoms. Genetic characterization and phylogenetic analysis of nearly complete CanineCV genomes suggested t...

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Autores principales:	Chutchai Piewbang, Wendy K. Jo, Christina Puff, Erhard van der Vries, Sawang Kesdangsakonwut, Anudep Rungsipipat, Jochen Kruppa, Klaus Jung, Wolfgang Baumgärtner, Somporn Techangamsuwan, Martin Ludlow, Albert D. M. E. Osterhaus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7aa6f9b37de846cd8dc119be723c302f
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spelling	oai:doaj.org-article:7aa6f9b37de846cd8dc119be723c302f2021-12-02T15:08:23ZNovel canine circovirus strains from Thailand: Evidence for genetic recombination10.1038/s41598-018-25936-12045-2322https://doaj.org/article/7aa6f9b37de846cd8dc119be723c302f2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25936-1https://doaj.org/toc/2045-2322Abstract Canine circoviruses (CanineCV’s), belonging to the genus Circovirus of the Circoviridae family, were detected by next generation sequencing in samples from Thai dogs with respiratory symptoms. Genetic characterization and phylogenetic analysis of nearly complete CanineCV genomes suggested that natural recombination had occurred among different lineages of CanineCV’s. Similarity plot and bootscaning analyses indicated that American and Chinese viruses had served as major and minor parental viruses, respectively. Positions of recombination breakpoints were estimated using maximum-likelihood frameworks with statistical significant testing. The putative recombination event was located in the Replicase gene, intersecting with open reading frame-3. Analysis of nucleotide changes confirmed the origin of the recombination event. This is the first description of naturally occurring recombinant CanineCV’s that have resulted in the circulation of newly emerging CanineCV lineages.Chutchai PiewbangWendy K. JoChristina PuffErhard van der VriesSawang KesdangsakonwutAnudep RungsipipatJochen KruppaKlaus JungWolfgang BaumgärtnerSomporn TechangamsuwanMartin LudlowAlbert D. M. E. OsterhausNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chutchai Piewbang Wendy K. Jo Christina Puff Erhard van der Vries Sawang Kesdangsakonwut Anudep Rungsipipat Jochen Kruppa Klaus Jung Wolfgang Baumgärtner Somporn Techangamsuwan Martin Ludlow Albert D. M. E. Osterhaus Novel canine circovirus strains from Thailand: Evidence for genetic recombination
description	Abstract Canine circoviruses (CanineCV’s), belonging to the genus Circovirus of the Circoviridae family, were detected by next generation sequencing in samples from Thai dogs with respiratory symptoms. Genetic characterization and phylogenetic analysis of nearly complete CanineCV genomes suggested that natural recombination had occurred among different lineages of CanineCV’s. Similarity plot and bootscaning analyses indicated that American and Chinese viruses had served as major and minor parental viruses, respectively. Positions of recombination breakpoints were estimated using maximum-likelihood frameworks with statistical significant testing. The putative recombination event was located in the Replicase gene, intersecting with open reading frame-3. Analysis of nucleotide changes confirmed the origin of the recombination event. This is the first description of naturally occurring recombinant CanineCV’s that have resulted in the circulation of newly emerging CanineCV lineages.
format	article
author	Chutchai Piewbang Wendy K. Jo Christina Puff Erhard van der Vries Sawang Kesdangsakonwut Anudep Rungsipipat Jochen Kruppa Klaus Jung Wolfgang Baumgärtner Somporn Techangamsuwan Martin Ludlow Albert D. M. E. Osterhaus
author_facet	Chutchai Piewbang Wendy K. Jo Christina Puff Erhard van der Vries Sawang Kesdangsakonwut Anudep Rungsipipat Jochen Kruppa Klaus Jung Wolfgang Baumgärtner Somporn Techangamsuwan Martin Ludlow Albert D. M. E. Osterhaus
author_sort	Chutchai Piewbang
title	Novel canine circovirus strains from Thailand: Evidence for genetic recombination
title_short	Novel canine circovirus strains from Thailand: Evidence for genetic recombination
title_full	Novel canine circovirus strains from Thailand: Evidence for genetic recombination
title_fullStr	Novel canine circovirus strains from Thailand: Evidence for genetic recombination
title_full_unstemmed	Novel canine circovirus strains from Thailand: Evidence for genetic recombination
title_sort	novel canine circovirus strains from thailand: evidence for genetic recombination
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7aa6f9b37de846cd8dc119be723c302f
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_version_	1718388129262469120

Novel canine circovirus strains from Thailand: Evidence for genetic recombination

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