JunB regulates homeostasis and suppressive functions of effector regulatory T cells

Regulatory T (Treg) cells need to be differentiated into effector Treg (eTreg), with the transcription factor IRF4 implicated during this process. Here the authors show that an AP-1 family transcription factor, JunB, is expressed in eTreg to promote the IRF4 transcription program, and regulate eTreg...

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Autores principales:	Shin-ichi Koizumi, Daiki Sasaki, Tsung-Han Hsieh, Naoyuki Taira, Nana Arakaki, Shinichi Yamasaki, Ke Wang, Shukla Sarkar, Hiroki Shirahata, Mio Miyagi, Hiroki Ishikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7aa833cf71e14ed6b77048af37da10b6
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spelling	oai:doaj.org-article:7aa833cf71e14ed6b77048af37da10b62021-12-02T17:32:45ZJunB regulates homeostasis and suppressive functions of effector regulatory T cells10.1038/s41467-018-07735-42041-1723https://doaj.org/article/7aa833cf71e14ed6b77048af37da10b62018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07735-4https://doaj.org/toc/2041-1723Regulatory T (Treg) cells need to be differentiated into effector Treg (eTreg), with the transcription factor IRF4 implicated during this process. Here the authors show that an AP-1 family transcription factor, JunB, is expressed in eTreg to promote the IRF4 transcription program, and regulate eTreg homeostasis and function.Shin-ichi KoizumiDaiki SasakiTsung-Han HsiehNaoyuki TairaNana ArakakiShinichi YamasakiKe WangShukla SarkarHiroki ShirahataMio MiyagiHiroki IshikawaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shin-ichi Koizumi Daiki Sasaki Tsung-Han Hsieh Naoyuki Taira Nana Arakaki Shinichi Yamasaki Ke Wang Shukla Sarkar Hiroki Shirahata Mio Miyagi Hiroki Ishikawa JunB regulates homeostasis and suppressive functions of effector regulatory T cells
description	Regulatory T (Treg) cells need to be differentiated into effector Treg (eTreg), with the transcription factor IRF4 implicated during this process. Here the authors show that an AP-1 family transcription factor, JunB, is expressed in eTreg to promote the IRF4 transcription program, and regulate eTreg homeostasis and function.
format	article
author	Shin-ichi Koizumi Daiki Sasaki Tsung-Han Hsieh Naoyuki Taira Nana Arakaki Shinichi Yamasaki Ke Wang Shukla Sarkar Hiroki Shirahata Mio Miyagi Hiroki Ishikawa
author_facet	Shin-ichi Koizumi Daiki Sasaki Tsung-Han Hsieh Naoyuki Taira Nana Arakaki Shinichi Yamasaki Ke Wang Shukla Sarkar Hiroki Shirahata Mio Miyagi Hiroki Ishikawa
author_sort	Shin-ichi Koizumi
title	JunB regulates homeostasis and suppressive functions of effector regulatory T cells
title_short	JunB regulates homeostasis and suppressive functions of effector regulatory T cells
title_full	JunB regulates homeostasis and suppressive functions of effector regulatory T cells
title_fullStr	JunB regulates homeostasis and suppressive functions of effector regulatory T cells
title_full_unstemmed	JunB regulates homeostasis and suppressive functions of effector regulatory T cells
title_sort	junb regulates homeostasis and suppressive functions of effector regulatory t cells
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7aa833cf71e14ed6b77048af37da10b6
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_version_	1718380197219139584

JunB regulates homeostasis and suppressive functions of effector regulatory T cells

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