PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized mice and provide evidence that PD-1 signaling alte...

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Autores principales:	Doumet Georges Helou, Pedram Shafiei-Jahani, Richard Lo, Emily Howard, Benjamin P. Hurrell, Lauriane Galle-Treger, Jacob D. Painter, Gavin Lewis, Pejman Soroosh, Arlene H. Sharpe, Omid Akbari
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f
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spelling	oai:doaj.org-article:7aaaa31742d140ac9e011cac9002ea8f2021-12-02T19:06:44ZPD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity10.1038/s41467-020-17813-12041-1723https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17813-1https://doaj.org/toc/2041-1723PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized mice and provide evidence that PD-1 signaling alters ILC2 function by modulation of cell metabolism.Doumet Georges HelouPedram Shafiei-JahaniRichard LoEmily HowardBenjamin P. HurrellLauriane Galle-TregerJacob D. PainterGavin LewisPejman SorooshArlene H. SharpeOmid AkbariNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Doumet Georges Helou Pedram Shafiei-Jahani Richard Lo Emily Howard Benjamin P. Hurrell Lauriane Galle-Treger Jacob D. Painter Gavin Lewis Pejman Soroosh Arlene H. Sharpe Omid Akbari PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
description	PD-1 is a checkpoint inhibitory immune receptor that restrains proliferation and effector functions of a variety of cells, including ILC2s. Here the authors present a human PD-1 agonist that limits ILC2-dependent allergic airway disease in humanized mice and provide evidence that PD-1 signaling alters ILC2 function by modulation of cell metabolism.
format	article
author	Doumet Georges Helou Pedram Shafiei-Jahani Richard Lo Emily Howard Benjamin P. Hurrell Lauriane Galle-Treger Jacob D. Painter Gavin Lewis Pejman Soroosh Arlene H. Sharpe Omid Akbari
author_facet	Doumet Georges Helou Pedram Shafiei-Jahani Richard Lo Emily Howard Benjamin P. Hurrell Lauriane Galle-Treger Jacob D. Painter Gavin Lewis Pejman Soroosh Arlene H. Sharpe Omid Akbari
author_sort	Doumet Georges Helou
title	PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
title_short	PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
title_full	PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
title_fullStr	PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
title_full_unstemmed	PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity
title_sort	pd-1 pathway regulates ilc2 metabolism and pd-1 agonist treatment ameliorates airway hyperreactivity
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7aaaa31742d140ac9e011cac9002ea8f
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PD-1 pathway regulates ILC2 metabolism and PD-1 agonist treatment ameliorates airway hyperreactivity

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