The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats

Abstract In patients with short bowel syndrome, an elevated pre-resection Body Mass Index may be protective of post-resection body composition. We hypothesized that rats with diet-induced obesity would lose less lean body mass after undergoing massive small bowel resection compared to non-obese rats...

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Autores principales:	Neesha S. Patel, Ujwal R. Yanala, Shruthishree Aravind, Roger D. Reidelberger, Jon S. Thompson, Mark A. Carlson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7aac6fad322a4404b3c37b78758e18d9
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spelling	oai:doaj.org-article:7aac6fad322a4404b3c37b78758e18d92021-12-02T17:44:54ZThe effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats10.1038/s41598-021-92510-72045-2322https://doaj.org/article/7aac6fad322a4404b3c37b78758e18d92021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92510-7https://doaj.org/toc/2045-2322Abstract In patients with short bowel syndrome, an elevated pre-resection Body Mass Index may be protective of post-resection body composition. We hypothesized that rats with diet-induced obesity would lose less lean body mass after undergoing massive small bowel resection compared to non-obese rats. Rats (CD IGS; age = 2 mo; N = 80) were randomly assigned to either a high-fat (obese rats) or a low-fat diet (non-obese rats), and fed ad lib for six months. Each diet group then was randomized to either underwent a 75% distal small bowel resection (massive resection) or small bowel transection with re-anastomosis (sham resection). All rats then were fed ad lib with an intermediate-fat diet (25% of total calories) for two months. Body weight and quantitative magnetic resonance-determined body composition were monitored. Preoperative body weight was 884 ± 95 versus 741 ± 75 g, and preoperative percent body fat was 35.8 ± 3.9 versus 24.9 ± 4.6%; high-fat vs. low fat diet, respectively (p < 0.0001); preoperative diet type had no effect on lean mass. Regarding total body weight, massive resection produced an 18% versus 5% decrease in high-fat versus low-fat rats respectively, while sham resection produced a 2% decrease vs. a 7% increase, respectively (p < 0.0001, preoperative vs. necropsy data). Sham resection had no effect on lean mass; after massive resection, both high-fat and low-fat rats lost lean mass, but these changes were not different between the latter two rat groups. The high-fat diet and low-fat diet induced obesity and marginal obesity, respectively. The massive resection produced greater weight loss in high-fat rats compared to low-fat rats. The type of dietary preconditioning had no effect on lean mass loss after massive resection. A protective effect of pre-existing obesity on lean mass after massive intestinal resection was not demonstrated.Neesha S. PatelUjwal R. YanalaShruthishree AravindRoger D. ReidelbergerJon S. ThompsonMark A. CarlsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Neesha S. Patel Ujwal R. Yanala Shruthishree Aravind Roger D. Reidelberger Jon S. Thompson Mark A. Carlson The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
description	Abstract In patients with short bowel syndrome, an elevated pre-resection Body Mass Index may be protective of post-resection body composition. We hypothesized that rats with diet-induced obesity would lose less lean body mass after undergoing massive small bowel resection compared to non-obese rats. Rats (CD IGS; age = 2 mo; N = 80) were randomly assigned to either a high-fat (obese rats) or a low-fat diet (non-obese rats), and fed ad lib for six months. Each diet group then was randomized to either underwent a 75% distal small bowel resection (massive resection) or small bowel transection with re-anastomosis (sham resection). All rats then were fed ad lib with an intermediate-fat diet (25% of total calories) for two months. Body weight and quantitative magnetic resonance-determined body composition were monitored. Preoperative body weight was 884 ± 95 versus 741 ± 75 g, and preoperative percent body fat was 35.8 ± 3.9 versus 24.9 ± 4.6%; high-fat vs. low fat diet, respectively (p < 0.0001); preoperative diet type had no effect on lean mass. Regarding total body weight, massive resection produced an 18% versus 5% decrease in high-fat versus low-fat rats respectively, while sham resection produced a 2% decrease vs. a 7% increase, respectively (p < 0.0001, preoperative vs. necropsy data). Sham resection had no effect on lean mass; after massive resection, both high-fat and low-fat rats lost lean mass, but these changes were not different between the latter two rat groups. The high-fat diet and low-fat diet induced obesity and marginal obesity, respectively. The massive resection produced greater weight loss in high-fat rats compared to low-fat rats. The type of dietary preconditioning had no effect on lean mass loss after massive resection. A protective effect of pre-existing obesity on lean mass after massive intestinal resection was not demonstrated.
format	article
author	Neesha S. Patel Ujwal R. Yanala Shruthishree Aravind Roger D. Reidelberger Jon S. Thompson Mark A. Carlson
author_facet	Neesha S. Patel Ujwal R. Yanala Shruthishree Aravind Roger D. Reidelberger Jon S. Thompson Mark A. Carlson
author_sort	Neesha S. Patel
title	The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
title_short	The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
title_full	The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
title_fullStr	The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
title_full_unstemmed	The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
title_sort	effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7aac6fad322a4404b3c37b78758e18d9
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The effect of pre-resection obesity on post-resection body composition after 75% small bowel resection in rats

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