Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography

Alex C Onishi, Alison D Treister, Peter L Nesper, Amani A Fawzi, Anupama R Anchala Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USACorrespondence: Anupama R AnchalaDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 64...

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Autores principales:	Onishi AC, Treister AD, Nesper PL, Fawzi AA, Anchala AR
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	macular vessel density high-tension glaucoma low-tension glaucoma retinal imaging Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7aada72a9c534fa9b26bc36f1fd175e8
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spelling	oai:doaj.org-article:7aada72a9c534fa9b26bc36f1fd175e82021-12-02T08:01:12ZParafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography1177-5483https://doaj.org/article/7aada72a9c534fa9b26bc36f1fd175e82019-09-01T00:00:00Zhttps://www.dovepress.com/parafoveal-vessel-changes-in-primary-open-angle-glaucoma-and-normal-te-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Alex C Onishi, Alison D Treister, Peter L Nesper, Amani A Fawzi, Anupama R Anchala Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USACorrespondence: Anupama R AnchalaDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 440, Chicago, IL 60611, USATel +1 312 908 8152Fax +1 312 503 8152Email aanchala@nm.orgPurpose: To evaluate parafoveal and peripapillary perfusion in healthy, glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma subjects.Patients and methods: This was a retrospective cross-sectional study with optical coherence tomography angiography imaging with RTVue XR Avanti (Optovue, Inc., Fremont, CA) of 56 eyes (14 healthy, 14 glaucoma suspect, 16 normal-tension glaucoma, and 12 primary open-angle glaucoma) at a tertiary academic referral center. Parafoveal and peripapillary superficial vessel density and parafoveal superficial retinal thickness were the main parameters of interest. Area under receiver operating characteristic curves were calculated.Results: There were significant decreases in parafoveal superficial vessel density in primary open-angle (40.06±4.54%, P<0.001) and normal-tension glaucoma (42.82±5.16%, P=0.010) but not suspect eyes (45.72±4.37%, P=0.916) compared to healthy eyes (48.10±2.82%). Similarly, decreases were observed in parafoveal inner retinal thickness in primary open-angle (83.19±14.29 μm, P<0.001) and normal-tension glaucoma eyes (94.97±12.44 μm, P=0.035), but not suspect eyes (99.93±9.00 μm, P=0.648), compared to healthy controls (107.00±9.55 μm). Only primary open-angle glaucoma eyes displayed significant changes in peripapillary vessel density (37.63±7.19%) compared to healthy controls (49.12±2.80%, P<0.001). Further statistical adjustment for sex and age revealed a significant decrease in parafoveal vessel density in suspects relative to controls (P=0.039). Diagnostic accuracy of parafoveal vessel density was high with an area under the curve of 0.833±0.073 for normal-tension glaucoma and 0.946±0.049 for primary open-angle glaucoma.Conclusion: Parafoveal vessel density was significantly reduced in glaucomatous eyes, with good diagnostic accuracy. These findings provide further evidence that these changes may be useful in the diagnosis and monitoring of disease in glaucoma patients.Keywords: macular vessel density, high-tension glaucoma, low-tension glaucoma, retinal imagingOnishi ACTreister ADNesper PLFawzi AAAnchala ARDove Medical Pressarticlemacular vessel densityhigh-tension glaucomalow-tension glaucomaretinal imagingOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1935-1945 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	macular vessel density high-tension glaucoma low-tension glaucoma retinal imaging Ophthalmology RE1-994
spellingShingle	macular vessel density high-tension glaucoma low-tension glaucoma retinal imaging Ophthalmology RE1-994 Onishi AC Treister AD Nesper PL Fawzi AA Anchala AR Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
description	Alex C Onishi, Alison D Treister, Peter L Nesper, Amani A Fawzi, Anupama R Anchala Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USACorrespondence: Anupama R AnchalaDepartment of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 440, Chicago, IL 60611, USATel +1 312 908 8152Fax +1 312 503 8152Email aanchala@nm.orgPurpose: To evaluate parafoveal and peripapillary perfusion in healthy, glaucoma suspect, normal-tension glaucoma, and primary open-angle glaucoma subjects.Patients and methods: This was a retrospective cross-sectional study with optical coherence tomography angiography imaging with RTVue XR Avanti (Optovue, Inc., Fremont, CA) of 56 eyes (14 healthy, 14 glaucoma suspect, 16 normal-tension glaucoma, and 12 primary open-angle glaucoma) at a tertiary academic referral center. Parafoveal and peripapillary superficial vessel density and parafoveal superficial retinal thickness were the main parameters of interest. Area under receiver operating characteristic curves were calculated.Results: There were significant decreases in parafoveal superficial vessel density in primary open-angle (40.06±4.54%, P<0.001) and normal-tension glaucoma (42.82±5.16%, P=0.010) but not suspect eyes (45.72±4.37%, P=0.916) compared to healthy eyes (48.10±2.82%). Similarly, decreases were observed in parafoveal inner retinal thickness in primary open-angle (83.19±14.29 μm, P<0.001) and normal-tension glaucoma eyes (94.97±12.44 μm, P=0.035), but not suspect eyes (99.93±9.00 μm, P=0.648), compared to healthy controls (107.00±9.55 μm). Only primary open-angle glaucoma eyes displayed significant changes in peripapillary vessel density (37.63±7.19%) compared to healthy controls (49.12±2.80%, P<0.001). Further statistical adjustment for sex and age revealed a significant decrease in parafoveal vessel density in suspects relative to controls (P=0.039). Diagnostic accuracy of parafoveal vessel density was high with an area under the curve of 0.833±0.073 for normal-tension glaucoma and 0.946±0.049 for primary open-angle glaucoma.Conclusion: Parafoveal vessel density was significantly reduced in glaucomatous eyes, with good diagnostic accuracy. These findings provide further evidence that these changes may be useful in the diagnosis and monitoring of disease in glaucoma patients.Keywords: macular vessel density, high-tension glaucoma, low-tension glaucoma, retinal imaging
format	article
author	Onishi AC Treister AD Nesper PL Fawzi AA Anchala AR
author_facet	Onishi AC Treister AD Nesper PL Fawzi AA Anchala AR
author_sort	Onishi AC
title	Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
title_short	Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
title_full	Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
title_fullStr	Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
title_full_unstemmed	Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
title_sort	parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7aada72a9c534fa9b26bc36f1fd175e8
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Parafoveal vessel changes in primary open-angle glaucoma and normal-tension glaucoma using optical coherence tomography angiography

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