Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy

BACKGROUND AND OBJECTIVE: Postoperative pain management is considered as a part of recovery. Duloxetine (DLX), an anti-depressant medication, is a possible choice for the multimodal anesthetic strategy. We aimed to evaluate the effect of Duloxetine on postoperative hysterectomy pain management in pa...

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Autores principales:	H Sattari, M Noroozi, M Hashemian, MR Doroodian, F Mansoori Nasab
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2020
Materias:	duloxetine hydrochloride postoperative pain hysterectomy analgesics opioid. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7aae137309a84e0181795d3d2ecb628a
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spelling	oai:doaj.org-article:7aae137309a84e0181795d3d2ecb628a2021-11-09T10:15:54ZEvaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy1561-41072251-7170https://doaj.org/article/7aae137309a84e0181795d3d2ecb628a2020-03-01T00:00:00Zhttp://jbums.org/article-1-8906-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Postoperative pain management is considered as a part of recovery. Duloxetine (DLX), an anti-depressant medication, is a possible choice for the multimodal anesthetic strategy. We aimed to evaluate the effect of Duloxetine on postoperative hysterectomy pain management in patients who underwent hysterectomy. METHODS: In this randomized double-blind clinical trial, 60 patients aged 18-85 years with ASA I and II who were candidates for hysterectomy were randomly assigned to two group of 30 patients taking duloxetine (60 mg capsule) or placebo (starch). Opioid use, postoperative pain due to visual analogue score, vital signs and quality of recovery (Recovery-40 form), vital signs before induction of anesthesia, immediately after surgery, at isoflurane induction and after surgery every 15 minutes were reviewed and compared in two groups. FINDINGS: The amount of opioids in the duloxetine group decreased insignificantly. Postoperative pain in recovery and ward in duloxetine group (2.7±0.99 and 1.8±0.66, respectively) compared to placebo group (4.86±1.51 and 4.86±1.51, respectively) decreased significantly (p= 0.006 in recovery and p= 0.001 in ward). The quality of improvement in recovery (156.22±24.25 in the duloxetine group and 125.48±16.49 in the placebo group) was in favor of the effectiveness of duloxetine (p= 0.001). CONCLUSION: In conclusion, DLX is a beneficial drug to be used in multimodal anesthesia strategy especially in improving postoperative pain and quality of recovery in abdominal hysterectomy.H SattariM NorooziM HashemianMR DoroodianF Mansoori NasabBabol University of Medical Sciencesarticleduloxetine hydrochloridepostoperative painhysterectomyanalgesicsopioid.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 22, Iss 1, Pp 203-209 (2020)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	duloxetine hydrochloride postoperative pain hysterectomy analgesics opioid. Medicine R Medicine (General) R5-920
spellingShingle	duloxetine hydrochloride postoperative pain hysterectomy analgesics opioid. Medicine R Medicine (General) R5-920 H Sattari M Noroozi M Hashemian MR Doroodian F Mansoori Nasab Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy
description	BACKGROUND AND OBJECTIVE: Postoperative pain management is considered as a part of recovery. Duloxetine (DLX), an anti-depressant medication, is a possible choice for the multimodal anesthetic strategy. We aimed to evaluate the effect of Duloxetine on postoperative hysterectomy pain management in patients who underwent hysterectomy. METHODS: In this randomized double-blind clinical trial, 60 patients aged 18-85 years with ASA I and II who were candidates for hysterectomy were randomly assigned to two group of 30 patients taking duloxetine (60 mg capsule) or placebo (starch). Opioid use, postoperative pain due to visual analogue score, vital signs and quality of recovery (Recovery-40 form), vital signs before induction of anesthesia, immediately after surgery, at isoflurane induction and after surgery every 15 minutes were reviewed and compared in two groups. FINDINGS: The amount of opioids in the duloxetine group decreased insignificantly. Postoperative pain in recovery and ward in duloxetine group (2.7±0.99 and 1.8±0.66, respectively) compared to placebo group (4.86±1.51 and 4.86±1.51, respectively) decreased significantly (p= 0.006 in recovery and p= 0.001 in ward). The quality of improvement in recovery (156.22±24.25 in the duloxetine group and 125.48±16.49 in the placebo group) was in favor of the effectiveness of duloxetine (p= 0.001). CONCLUSION: In conclusion, DLX is a beneficial drug to be used in multimodal anesthesia strategy especially in improving postoperative pain and quality of recovery in abdominal hysterectomy.
format	article
author	H Sattari M Noroozi M Hashemian MR Doroodian F Mansoori Nasab
author_facet	H Sattari M Noroozi M Hashemian MR Doroodian F Mansoori Nasab
author_sort	H Sattari
title	Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy
title_short	Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy
title_full	Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy
title_fullStr	Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy
title_full_unstemmed	Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy
title_sort	evaluating the effect of preoperative duloxetine administration on postoperative pain in patients under abdominal hysterectomy
publisher	Babol University of Medical Sciences
publishDate	2020
url	https://doaj.org/article/7aae137309a84e0181795d3d2ecb628a
work_keys_str_mv	AT hsattari evaluatingtheeffectofpreoperativeduloxetineadministrationonpostoperativepaininpatientsunderabdominalhysterectomy AT mnoroozi evaluatingtheeffectofpreoperativeduloxetineadministrationonpostoperativepaininpatientsunderabdominalhysterectomy AT mhashemian evaluatingtheeffectofpreoperativeduloxetineadministrationonpostoperativepaininpatientsunderabdominalhysterectomy AT mrdoroodian evaluatingtheeffectofpreoperativeduloxetineadministrationonpostoperativepaininpatientsunderabdominalhysterectomy AT fmansoorinasab evaluatingtheeffectofpreoperativeduloxetineadministrationonpostoperativepaininpatientsunderabdominalhysterectomy
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Evaluating the Effect of Preoperative Duloxetine Administration on Postoperative Pain in Patients under Abdominal Hysterectomy

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