Phosphorylation of Lamin A/C at serine 22 modulates Nav1.5 function

Abstract Variants in the LMNA gene, which encodes for Lamin A/C, are associated with cardiac conduction disease (CCD). We previously reported that Lamin A/C variants p.R545H and p.A287Lfs*193, which were identified in CCD patients, decreased peak INa in HEK‐293 cells expressing Nav1.5. Decreased pea...

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Bibliographic Details
Main Authors: Michael A. Olaopa, Tomohiko Ai, Bo Chao, Xiangshu Xiao, Matteo Vatta, Beth A. Habecker
Format: article
Language:EN
Published: Wiley 2021
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Online Access:https://doaj.org/article/7aaf40cbff3446268244b82cff02bd1c
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