To Defend or Not To Defend: That’s the Question

ABSTRACT Enterococcus faecalis is an opportunistic pathogen and is one of the leading causes of nosocomial infections. E. faecalis harbors a number of antibiotic resistance genes, and most of these are present on mobile genetic elements (MGEs) that can be disseminated within the species, as well as...

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Autores principales:	Sriram Varahan, Lynn E. Hancock
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	CRISPR Enterococcus faecalis antibiotic resistance Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7ab4f46caf3a40508c428cd99c720eee
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spelling	oai:doaj.org-article:7ab4f46caf3a40508c428cd99c720eee2021-11-15T15:21:18ZTo Defend or Not To Defend: That’s the Question10.1128/mSphere.00127-162379-5042https://doaj.org/article/7ab4f46caf3a40508c428cd99c720eee2016-06-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSphere.00127-16https://doaj.org/toc/2379-5042ABSTRACT Enterococcus faecalis is an opportunistic pathogen and is one of the leading causes of nosocomial infections. E. faecalis harbors a number of antibiotic resistance genes, and most of these are present on mobile genetic elements (MGEs) that can be disseminated within the species, as well as to other members of the human microflora. In an article by Price and colleagues [V. J. Price et al., mSphere 1(3):e00064-16, 2016, http://dx.doi.org/10.1128/mSphere.00064-16 ], the authors demonstrated how E. faecalis uses a restriction-modification system along with a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas to function as a bacterial innate and adaptive immune system to regulate the influx of MGEs. The absence of these systems in high-risk hospital-adapted lineages of E. faecalis, including the prototypical V583 strain, appears to allow the ready acquisition of new traits that aid in the adaptation to new environmental stresses, including the evolution of resistance to many of our best antibiotics.Sriram VarahanLynn E. HancockAmerican Society for MicrobiologyarticleCRISPREnterococcus faecalisantibiotic resistanceMicrobiologyQR1-502ENmSphere, Vol 1, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	CRISPR Enterococcus faecalis antibiotic resistance Microbiology QR1-502
spellingShingle	CRISPR Enterococcus faecalis antibiotic resistance Microbiology QR1-502 Sriram Varahan Lynn E. Hancock To Defend or Not To Defend: That’s the Question
description	ABSTRACT Enterococcus faecalis is an opportunistic pathogen and is one of the leading causes of nosocomial infections. E. faecalis harbors a number of antibiotic resistance genes, and most of these are present on mobile genetic elements (MGEs) that can be disseminated within the species, as well as to other members of the human microflora. In an article by Price and colleagues [V. J. Price et al., mSphere 1(3):e00064-16, 2016, http://dx.doi.org/10.1128/mSphere.00064-16 ], the authors demonstrated how E. faecalis uses a restriction-modification system along with a clustered regularly interspaced short palindromic repeat (CRISPR)-Cas to function as a bacterial innate and adaptive immune system to regulate the influx of MGEs. The absence of these systems in high-risk hospital-adapted lineages of E. faecalis, including the prototypical V583 strain, appears to allow the ready acquisition of new traits that aid in the adaptation to new environmental stresses, including the evolution of resistance to many of our best antibiotics.
format	article
author	Sriram Varahan Lynn E. Hancock
author_facet	Sriram Varahan Lynn E. Hancock
author_sort	Sriram Varahan
title	To Defend or Not To Defend: That’s the Question
title_short	To Defend or Not To Defend: That’s the Question
title_full	To Defend or Not To Defend: That’s the Question
title_fullStr	To Defend or Not To Defend: That’s the Question
title_full_unstemmed	To Defend or Not To Defend: That’s the Question
title_sort	to defend or not to defend: that’s the question
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/7ab4f46caf3a40508c428cd99c720eee
work_keys_str_mv	AT sriramvarahan todefendornottodefendthatsthequestion AT lynnehancock todefendornottodefendthatsthequestion
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To Defend or Not To Defend: That’s the Question

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