Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months

Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months

Abstract The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infan...

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Autores principales: Livio Provenzi, Fabiana Mambretti, Marco Villa, Serena Grumi, Andrea Citterio, Emanuela Bertazzoli, Giacomo Biasucci, Lidia Decembrino, Rossana Falcone, Barbara Gardella, Maria Roberta Longo, Renata Nacinovich, Camilla Pisoni, Federico Prefumo, Simona Orcesi, Barbara Scelsa, Roberto Giorda, Renato Borgatti
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/7ab738b66d9b4f188e9ca8680061ab17
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spelling oai:doaj.org-article:7ab738b66d9b4f188e9ca8680061ab172021-12-02T18:49:29ZHidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months10.1038/s41598-021-95053-z2045-2322https://doaj.org/article/7ab738b66d9b4f188e9ca8680061ab172021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95053-zhttps://doaj.org/toc/2045-2322Abstract The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.Livio ProvenziFabiana MambrettiMarco VillaSerena GrumiAndrea CitterioEmanuela BertazzoliGiacomo BiasucciLidia DecembrinoRossana FalconeBarbara GardellaMaria Roberta LongoRenata NacinovichCamilla PisoniFederico PrefumoSimona OrcesiBarbara ScelsaRoberto GiordaRenato BorgattiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Livio Provenzi
Fabiana Mambretti
Marco Villa
Serena Grumi
Andrea Citterio
Emanuela Bertazzoli
Giacomo Biasucci
Lidia Decembrino
Rossana Falcone
Barbara Gardella
Maria Roberta Longo
Renata Nacinovich
Camilla Pisoni
Federico Prefumo
Simona Orcesi
Barbara Scelsa
Roberto Giorda
Renato Borgatti
Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
description Abstract The COVID-19 pandemic represents a collective trauma that may have enduring stress effects during sensitive periods, such as pregnancy. Prenatal stress may result in epigenetic signatures of stress-related genes (e.g., the serotonin transporter gene, SLC6A4) that may in turn influence infants’ behavioral development. In April 2020, we launched a longitudinal cohort study to assess the behavioral and epigenetic vestiges of COVID-19-related prenatal stress exposure in mothers and infants. COVID-19-related prenatal stress was retrospectively assessed at birth. SLC6A4 methylation was assessed in thirteen CpG sites in mothers and infants’ buccal cells. Infants’ temperament was assessed at 3-month-age. Complete data were available from 108 mother-infant dyads. Greater COVID-19-related prenatal stress was significantly associated with higher infants’ SLC6A4 methylation in seven CpG sites. SLC6A4 methylation at these sites predicted infants’ temperament at 3 months.
format article
author Livio Provenzi
Fabiana Mambretti
Marco Villa
Serena Grumi
Andrea Citterio
Emanuela Bertazzoli
Giacomo Biasucci
Lidia Decembrino
Rossana Falcone
Barbara Gardella
Maria Roberta Longo
Renata Nacinovich
Camilla Pisoni
Federico Prefumo
Simona Orcesi
Barbara Scelsa
Roberto Giorda
Renato Borgatti
author_facet Livio Provenzi
Fabiana Mambretti
Marco Villa
Serena Grumi
Andrea Citterio
Emanuela Bertazzoli
Giacomo Biasucci
Lidia Decembrino
Rossana Falcone
Barbara Gardella
Maria Roberta Longo
Renata Nacinovich
Camilla Pisoni
Federico Prefumo
Simona Orcesi
Barbara Scelsa
Roberto Giorda
Renato Borgatti
author_sort Livio Provenzi
title Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
title_short Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
title_full Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
title_fullStr Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
title_full_unstemmed Hidden pandemic: COVID-19-related stress, SLC6A4 methylation, and infants’ temperament at 3 months
title_sort hidden pandemic: covid-19-related stress, slc6a4 methylation, and infants’ temperament at 3 months
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7ab738b66d9b4f188e9ca8680061ab17
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