EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression of other lineages through upregulation of Spi1/PU...

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Autores principales:	Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
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spelling	oai:doaj.org-article:7ab778ef571e43deb286e077ef67c6402021-12-02T16:56:56ZEVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription10.1038/s41467-018-06208-y2041-1723https://doaj.org/article/7ab778ef571e43deb286e077ef67c6402018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06208-yhttps://doaj.org/toc/2041-1723Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression of other lineages through upregulation of Spi1/PU.1.Edward AyoubMichael P. WilsonKathleen E. McGrathAllison J. LiBenjamin J. FrischJames PalisLaura M. CalviYi ZhangArchibald S. PerkinsNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Edward Ayoub Michael P. Wilson Kathleen E. McGrath Allison J. Li Benjamin J. Frisch James Palis Laura M. Calvi Yi Zhang Archibald S. Perkins EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
description	Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression of other lineages through upregulation of Spi1/PU.1.
format	article
author	Edward Ayoub Michael P. Wilson Kathleen E. McGrath Allison J. Li Benjamin J. Frisch James Palis Laura M. Calvi Yi Zhang Archibald S. Perkins
author_facet	Edward Ayoub Michael P. Wilson Kathleen E. McGrath Allison J. Li Benjamin J. Frisch James Palis Laura M. Calvi Yi Zhang Archibald S. Perkins
author_sort	Edward Ayoub
title	EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
title_short	EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
title_full	EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
title_fullStr	EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
title_full_unstemmed	EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
title_sort	evi1 overexpression reprograms hematopoiesis via upregulation of spi1 transcription
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/7ab778ef571e43deb286e077ef67c640
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EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription

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