EVI1 overexpression reprograms hematopoiesis via upregulation of Spi1 transcription
Chr3q26 rearrangements cause overexpression of EVI1 and associate with myeloid neoplasms, but the mechanism behind this association is unclear. Here, using a novel mouse model they show that EVI1 causes premalignant myeloid expansion with suppression of other lineages through upregulation of Spi1/PU...
Guardado en:
Autores principales: | Edward Ayoub, Michael P. Wilson, Kathleen E. McGrath, Allison J. Li, Benjamin J. Frisch, James Palis, Laura M. Calvi, Yi Zhang, Archibald S. Perkins |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/7ab778ef571e43deb286e077ef67c640 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia.
por: Carolyn Glass, et al.
Publicado: (2013) -
EVI1 inhibits apoptosis induced by antileukemic drugs via upregulation of CDKN1A/p21/WAF in human myeloid cells.
por: Anna Rommer, et al.
Publicado: (2013) -
Long noncoding RNA NR2F1-AS1 plays a carcinogenic role in gastric cancer by recruiting transcriptional factor SPI1 to upregulate ST8SIA1 expression
por: Fang Zuo, et al.
Publicado: (2021) -
Spy&Go purification of SpyTag-proteins using pseudo-SpyCatcher to access an oligomerization toolbox
por: Irsyad N. A. Khairil Anuar, et al.
Publicado: (2019) -
One-step construction of circularized nanodiscs using SpyCatcher-SpyTag
por: Shanwen Zhang, et al.
Publicado: (2021)