Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers.

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Autores principales:	Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ab848514085441b822b8a2f77f90739
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spelling	oai:doaj.org-article:7ab848514085441b822b8a2f77f907392021-12-02T16:58:23ZStructural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 210.1038/ncomms113162041-1723https://doaj.org/article/7ab848514085441b822b8a2f77f907392016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11316https://doaj.org/toc/2041-1723Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers.Neil JustinYing ZhangCataldo TarriconeStephen R. MartinShuyang ChenElizabeth UnderwoodValeria De MarcoLesley F. HairePhilip A. WalkerDanny ReinbergJon R. WilsonSteven J. GamblinNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Neil Justin Ying Zhang Cataldo Tarricone Stephen R. Martin Shuyang Chen Elizabeth Underwood Valeria De Marco Lesley F. Haire Philip A. Walker Danny Reinberg Jon R. Wilson Steven J. Gamblin Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
description	Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers.
format	article
author	Neil Justin Ying Zhang Cataldo Tarricone Stephen R. Martin Shuyang Chen Elizabeth Underwood Valeria De Marco Lesley F. Haire Philip A. Walker Danny Reinberg Jon R. Wilson Steven J. Gamblin
author_facet	Neil Justin Ying Zhang Cataldo Tarricone Stephen R. Martin Shuyang Chen Elizabeth Underwood Valeria De Marco Lesley F. Haire Philip A. Walker Danny Reinberg Jon R. Wilson Steven J. Gamblin
author_sort	Neil Justin
title	Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
title_short	Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
title_full	Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
title_fullStr	Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
title_full_unstemmed	Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
title_sort	structural basis of oncogenic histone h3k27m inhibition of human polycomb repressive complex 2
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7ab848514085441b822b8a2f77f90739
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Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

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