Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2

Polycomb repressive complex 2 (PRC2) silences gene expression through trimethylation of K27 of histone H3 (H3K27Me). Here, the authors report the structure of the human PRC2 complex bound to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers.

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Autores principales: Neil Justin, Ying Zhang, Cataldo Tarricone, Stephen R. Martin, Shuyang Chen, Elizabeth Underwood, Valeria De Marco, Lesley F. Haire, Philip A. Walker, Danny Reinberg, Jon R. Wilson, Steven J. Gamblin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Science
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Acceso en línea:https://doaj.org/article/7ab848514085441b822b8a2f77f90739
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https://doaj.org/article/7ab848514085441b822b8a2f77f90739

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