TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There...

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Autores principales:	Estela Morales Peralta, Yaíma Zúñiga Rosales, Teresa Collazo Mesa, Elvia Nelmi Santos González, Yadira Hernández Pérez, María de los Ángeles González Torres, Hilda Roblejo Balbuena, Beatriz Marcheco Teruel
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	COVID-19 Genetic polymorphism Cuba Alleles Vitamin D Receptor Medicine (General) R5-920 Genetics QH426-470
Acceso en línea:	https://doaj.org/article/7abb50e1c3864dfdb07bcf809449c8c2
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spelling	oai:doaj.org-article:7abb50e1c3864dfdb07bcf809449c8c22021-12-05T12:05:05ZTaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients10.1186/s43042-021-00206-42090-2441https://doaj.org/article/7abb50e1c3864dfdb07bcf809449c8c22021-11-01T00:00:00Zhttps://doi.org/10.1186/s43042-021-00206-4https://doaj.org/toc/2090-2441Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.Estela Morales PeraltaYaíma Zúñiga RosalesTeresa Collazo MesaElvia Nelmi Santos GonzálezYadira Hernández PérezMaría de los Ángeles González TorresHilda Roblejo BalbuenaBeatriz Marcheco TeruelSpringerOpenarticleCOVID-19Genetic polymorphismCubaAllelesVitamin DReceptorMedicine (General)R5-920GeneticsQH426-470ENEgyptian Journal of Medical Human Genetics, Vol 22, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 Genetic polymorphism Cuba Alleles Vitamin D Receptor Medicine (General) R5-920 Genetics QH426-470
spellingShingle	COVID-19 Genetic polymorphism Cuba Alleles Vitamin D Receptor Medicine (General) R5-920 Genetics QH426-470 Estela Morales Peralta Yaíma Zúñiga Rosales Teresa Collazo Mesa Elvia Nelmi Santos González Yadira Hernández Pérez María de los Ángeles González Torres Hilda Roblejo Balbuena Beatriz Marcheco Teruel TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
description	Abstract Purpose To determine the relationship between the genotypes of the TaqI polymorphism of VDR gene and the clinical forms of COVID-19 in Cuban patients. Methods TaqI polymorphism was determined by the PCR in 104 Cuban patients, who suffered different clinical forms of COVID-19. Results There was a greater possibility of presenting symptomatic forms [OR = 2.081, 95% CI: 0.243–17.842], even severe [OR = 1.200, 95% CI: 0.217–6.638], related to the tt genotype. Conclusion There are signs of association between the risk of developing COVID-19 and the genotypes of the TaqI polymorphism of the VDR gene in the studied Cuban patients.
format	article
author	Estela Morales Peralta Yaíma Zúñiga Rosales Teresa Collazo Mesa Elvia Nelmi Santos González Yadira Hernández Pérez María de los Ángeles González Torres Hilda Roblejo Balbuena Beatriz Marcheco Teruel
author_facet	Estela Morales Peralta Yaíma Zúñiga Rosales Teresa Collazo Mesa Elvia Nelmi Santos González Yadira Hernández Pérez María de los Ángeles González Torres Hilda Roblejo Balbuena Beatriz Marcheco Teruel
author_sort	Estela Morales Peralta
title	TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_short	TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_full	TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_fullStr	TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_full_unstemmed	TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients
title_sort	taqi polymorphism of the vdr gene: aspects related to the clinical behavior of covid-19 in cuban patients
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/7abb50e1c3864dfdb07bcf809449c8c2
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TaqI polymorphism of the VDR gene: aspects related to the clinical behavior of COVID-19 in Cuban patients

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