Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.
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Nature Portfolio
2021
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oai:doaj.org-article:7abf996e0f9d4da6b7b08529e0aeb2062021-11-08T11:06:59ZPotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants10.1038/s41467-021-26539-72041-1723https://doaj.org/article/7abf996e0f9d4da6b7b08529e0aeb2062021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26539-7https://doaj.org/toc/2041-1723Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM.Tingting LiXiaojian HanChenjian GuHangtian GuoHuajun ZhangYingming WangChao HuKai WangFengjiang LiuFeiyang LuoYanan ZhangJie HuWang WangShenglong LiYanan HaoMeiying ShenJingjing HuangYingyi LongShuyi SongRuixin WuSong MuQian ChenFengxia GaoJianwei WangShunhua LongLuo LiYang WuYan GaoWei XuXia CaiDi QuZherui ZhangHongqing ZhangNa LiQingzhu GaoGuiji ZhangChanglong HeWei WangXiaoyun JiNi TangZhenghong YuanYouhua XieHaitao YangBo ZhangAilong HuangAishun JinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Tingting Li Xiaojian Han Chenjian Gu Hangtian Guo Huajun Zhang Yingming Wang Chao Hu Kai Wang Fengjiang Liu Feiyang Luo Yanan Zhang Jie Hu Wang Wang Shenglong Li Yanan Hao Meiying Shen Jingjing Huang Yingyi Long Shuyi Song Ruixin Wu Song Mu Qian Chen Fengxia Gao Jianwei Wang Shunhua Long Luo Li Yang Wu Yan Gao Wei Xu Xia Cai Di Qu Zherui Zhang Hongqing Zhang Na Li Qingzhu Gao Guiji Zhang Changlong He Wei Wang Xiaoyun Ji Ni Tang Zhenghong Yuan Youhua Xie Haitao Yang Bo Zhang Ailong Huang Aishun Jin Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| description |
Neutralizing antibodies are currently one versatile strategy to treat SARS-CoV-2 infection. Here, Li et al. characterize three monoclonal antibodies neutralizing authentic virus infection in vitro and in vivo by targeting the receptor binding domain as evidenced by Cryo-EM. |
| format |
article |
| author |
Tingting Li Xiaojian Han Chenjian Gu Hangtian Guo Huajun Zhang Yingming Wang Chao Hu Kai Wang Fengjiang Liu Feiyang Luo Yanan Zhang Jie Hu Wang Wang Shenglong Li Yanan Hao Meiying Shen Jingjing Huang Yingyi Long Shuyi Song Ruixin Wu Song Mu Qian Chen Fengxia Gao Jianwei Wang Shunhua Long Luo Li Yang Wu Yan Gao Wei Xu Xia Cai Di Qu Zherui Zhang Hongqing Zhang Na Li Qingzhu Gao Guiji Zhang Changlong He Wei Wang Xiaoyun Ji Ni Tang Zhenghong Yuan Youhua Xie Haitao Yang Bo Zhang Ailong Huang Aishun Jin |
| author_facet |
Tingting Li Xiaojian Han Chenjian Gu Hangtian Guo Huajun Zhang Yingming Wang Chao Hu Kai Wang Fengjiang Liu Feiyang Luo Yanan Zhang Jie Hu Wang Wang Shenglong Li Yanan Hao Meiying Shen Jingjing Huang Yingyi Long Shuyi Song Ruixin Wu Song Mu Qian Chen Fengxia Gao Jianwei Wang Shunhua Long Luo Li Yang Wu Yan Gao Wei Xu Xia Cai Di Qu Zherui Zhang Hongqing Zhang Na Li Qingzhu Gao Guiji Zhang Changlong He Wei Wang Xiaoyun Ji Ni Tang Zhenghong Yuan Youhua Xie Haitao Yang Bo Zhang Ailong Huang Aishun Jin |
| author_sort |
Tingting Li |
| title |
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| title_short |
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| title_full |
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| title_fullStr |
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| title_full_unstemmed |
Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| title_sort |
potent sars-cov-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/7abf996e0f9d4da6b7b08529e0aeb206 |
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