Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells

The precise cellular patterning and decisions of early embryogenesis have been hard to mimic in vitro. Here, the authors culture murine embryonic and trophoblast stem cells together with extra-embryonic endoderm stem cells to form embryo-like structures (ETX-embryoids), which can initiate an implant...

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Autores principales: Shaopeng Zhang, Tianzhi Chen, Naixin Chen, Dengfeng Gao, Bingbo Shi, Shuangbo Kong, Rachel Claire West, Ye Yuan, Minglei Zhi, Qingqing Wei, Jinzhu Xiang, Haiyuan Mu, Liang Yue, Xiaohua Lei, Xuepeng Wang, Liang Zhong, Hui Liang, Suying Cao, Juan Carlos Izpisua Belmonte, Haibin Wang, Jianyong Han
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/7ac0b1da37484bc9a2f0c73efcf90ab1
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spelling oai:doaj.org-article:7ac0b1da37484bc9a2f0c73efcf90ab12021-12-02T15:35:31ZImplantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells10.1038/s41467-019-08378-92041-1723https://doaj.org/article/7ac0b1da37484bc9a2f0c73efcf90ab12019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08378-9https://doaj.org/toc/2041-1723The precise cellular patterning and decisions of early embryogenesis have been hard to mimic in vitro. Here, the authors culture murine embryonic and trophoblast stem cells together with extra-embryonic endoderm stem cells to form embryo-like structures (ETX-embryoids), which can initiate an implantation response.Shaopeng ZhangTianzhi ChenNaixin ChenDengfeng GaoBingbo ShiShuangbo KongRachel Claire WestYe YuanMinglei ZhiQingqing WeiJinzhu XiangHaiyuan MuLiang YueXiaohua LeiXuepeng WangLiang ZhongHui LiangSuying CaoJuan Carlos Izpisua BelmonteHaibin WangJianyong HanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Shaopeng Zhang
Tianzhi Chen
Naixin Chen
Dengfeng Gao
Bingbo Shi
Shuangbo Kong
Rachel Claire West
Ye Yuan
Minglei Zhi
Qingqing Wei
Jinzhu Xiang
Haiyuan Mu
Liang Yue
Xiaohua Lei
Xuepeng Wang
Liang Zhong
Hui Liang
Suying Cao
Juan Carlos Izpisua Belmonte
Haibin Wang
Jianyong Han
Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
description The precise cellular patterning and decisions of early embryogenesis have been hard to mimic in vitro. Here, the authors culture murine embryonic and trophoblast stem cells together with extra-embryonic endoderm stem cells to form embryo-like structures (ETX-embryoids), which can initiate an implantation response.
format article
author Shaopeng Zhang
Tianzhi Chen
Naixin Chen
Dengfeng Gao
Bingbo Shi
Shuangbo Kong
Rachel Claire West
Ye Yuan
Minglei Zhi
Qingqing Wei
Jinzhu Xiang
Haiyuan Mu
Liang Yue
Xiaohua Lei
Xuepeng Wang
Liang Zhong
Hui Liang
Suying Cao
Juan Carlos Izpisua Belmonte
Haibin Wang
Jianyong Han
author_facet Shaopeng Zhang
Tianzhi Chen
Naixin Chen
Dengfeng Gao
Bingbo Shi
Shuangbo Kong
Rachel Claire West
Ye Yuan
Minglei Zhi
Qingqing Wei
Jinzhu Xiang
Haiyuan Mu
Liang Yue
Xiaohua Lei
Xuepeng Wang
Liang Zhong
Hui Liang
Suying Cao
Juan Carlos Izpisua Belmonte
Haibin Wang
Jianyong Han
author_sort Shaopeng Zhang
title Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
title_short Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
title_full Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
title_fullStr Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
title_full_unstemmed Implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
title_sort implantation initiation of self-assembled embryo-like structures generated using three types of mouse blastocyst-derived stem cells
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/7ac0b1da37484bc9a2f0c73efcf90ab1
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