Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing

The normal wound healing process is characterized by a complex, highly integrated cascade of events, requiring the interactions of many cell types, including inflammatory cells, fibroblasts, keratinocytes and endothelial cells, as well as the involvement of growth factors and enzymes. However, sever...

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Autores principales:	Mariarosaria Galeano, Giovanni Pallio, Natasha Irrera, Federica Mannino, Alessandra Bitto, Domenica Altavilla, Mario Vaccaro, Giovanni Squadrito, Vincenzo Arcoraci, Michele Rosario Colonna, Rita Lauro, Francesco Squadrito
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	polydeoxyribonucleotide PDRN adenosine receptors wound healing Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/7ac0d2d00ce84a4e851d6f633ec20f98
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spelling	oai:doaj.org-article:7ac0d2d00ce84a4e851d6f633ec20f982021-11-25T18:39:22ZPolydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing10.3390/ph141111031424-8247https://doaj.org/article/7ac0d2d00ce84a4e851d6f633ec20f982021-10-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1103https://doaj.org/toc/1424-8247The normal wound healing process is characterized by a complex, highly integrated cascade of events, requiring the interactions of many cell types, including inflammatory cells, fibroblasts, keratinocytes and endothelial cells, as well as the involvement of growth factors and enzymes. However, several diseases such as diabetes, thermal injury and ischemia could lead to an impaired wound healing process characterized by wound hypoxia, high levels of oxygen radicals, reduced angiogenesis, decreased collagen synthesis and organization. Polydeoxyribonucleotide (PDRN) has been used to improve wound healing through local and systemic administration thanks to its ability to promote cell migration and growth, angiogenesis, and to reduce inflammation on impaired wound healing models in vitro, in vivo and clinical studies. In light of all these observations, the aim of this review is to provide a full overview of PDRN applications on skin regeneration. We reviewed papers published in the last 25 years on PubMed, inserting “polydeoxyribonucleotide and wound healing” as the main search term. All data obtained proved the ability of PDRN in promoting physiological tissue repair through adenosine A<sub>2A</sub> receptor activation and salvage pathway suggesting that PDRN has proven encouraging results in terms of healing time, wound regeneration and absence of side effects.Mariarosaria GaleanoGiovanni PallioNatasha IrreraFederica ManninoAlessandra BittoDomenica AltavillaMario VaccaroGiovanni SquadritoVincenzo ArcoraciMichele Rosario ColonnaRita LauroFrancesco SquadritoMDPI AGarticlepolydeoxyribonucleotidePDRNadenosine receptorswound healingMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1103, p 1103 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polydeoxyribonucleotide PDRN adenosine receptors wound healing Medicine R Pharmacy and materia medica RS1-441
spellingShingle	polydeoxyribonucleotide PDRN adenosine receptors wound healing Medicine R Pharmacy and materia medica RS1-441 Mariarosaria Galeano Giovanni Pallio Natasha Irrera Federica Mannino Alessandra Bitto Domenica Altavilla Mario Vaccaro Giovanni Squadrito Vincenzo Arcoraci Michele Rosario Colonna Rita Lauro Francesco Squadrito Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
description	The normal wound healing process is characterized by a complex, highly integrated cascade of events, requiring the interactions of many cell types, including inflammatory cells, fibroblasts, keratinocytes and endothelial cells, as well as the involvement of growth factors and enzymes. However, several diseases such as diabetes, thermal injury and ischemia could lead to an impaired wound healing process characterized by wound hypoxia, high levels of oxygen radicals, reduced angiogenesis, decreased collagen synthesis and organization. Polydeoxyribonucleotide (PDRN) has been used to improve wound healing through local and systemic administration thanks to its ability to promote cell migration and growth, angiogenesis, and to reduce inflammation on impaired wound healing models in vitro, in vivo and clinical studies. In light of all these observations, the aim of this review is to provide a full overview of PDRN applications on skin regeneration. We reviewed papers published in the last 25 years on PubMed, inserting “polydeoxyribonucleotide and wound healing” as the main search term. All data obtained proved the ability of PDRN in promoting physiological tissue repair through adenosine A<sub>2A</sub> receptor activation and salvage pathway suggesting that PDRN has proven encouraging results in terms of healing time, wound regeneration and absence of side effects.
format	article
author	Mariarosaria Galeano Giovanni Pallio Natasha Irrera Federica Mannino Alessandra Bitto Domenica Altavilla Mario Vaccaro Giovanni Squadrito Vincenzo Arcoraci Michele Rosario Colonna Rita Lauro Francesco Squadrito
author_facet	Mariarosaria Galeano Giovanni Pallio Natasha Irrera Federica Mannino Alessandra Bitto Domenica Altavilla Mario Vaccaro Giovanni Squadrito Vincenzo Arcoraci Michele Rosario Colonna Rita Lauro Francesco Squadrito
author_sort	Mariarosaria Galeano
title	Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
title_short	Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
title_full	Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
title_fullStr	Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
title_full_unstemmed	Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing
title_sort	polydeoxyribonucleotide: a promising biological platform to accelerate impaired skin wound healing
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7ac0d2d00ce84a4e851d6f633ec20f98
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Polydeoxyribonucleotide: A Promising Biological Platform to Accelerate Impaired Skin Wound Healing

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