The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.

<h4>Background</h4>Adiponectin directly protects against cardiac remodeling. Despite this beneficial effect, most epidemiological studies have reported a negative relationship between adiponectin level and left ventricular mass index (LVMI). However, a positive relationship has also been...

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Autores principales:	Yonggu Lee, Bae Keun Kim, Young-Hyo Lim, Mi Kyung Kim, Bo Youl Choi, Jinho Shin
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7ac56f84f38a4c3a89fff7b2c1e93ad1
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spelling	oai:doaj.org-article:7ac56f84f38a4c3a89fff7b2c1e93ad12021-11-18T09:03:03ZThe relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.1932-620310.1371/journal.pone.0070246https://doaj.org/article/7ac56f84f38a4c3a89fff7b2c1e93ad12013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23894624/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Adiponectin directly protects against cardiac remodeling. Despite this beneficial effect, most epidemiological studies have reported a negative relationship between adiponectin level and left ventricular mass index (LVMI). However, a positive relationship has also been reported in subjects at high risk of left ventricular hypertrophy (LVH). Based on these conflicting results, we hypothesized that the relationship between serum adiponectin level and LVMI varies with the risk of LVH.<h4>Methods</h4>A community-based, cross-sectional study was performed on 1414 subjects. LVMI was measured by echocardiography. Log-transformed adiponectin levels (Log-ADPN) were used for the analysis.<h4>Results</h4>Serum adiponectin level had a biphasic distribution (an increase after a decrease) with increasing LVMI. Although Log-ADPN did not correlate with LVMI, Log-ADPN was modestly associated with LVMI in the multivariate analysis (β = 0.079, p = 0.001). The relationship between adiponectin level and LVMI was bidirectional according to the risk of LVH. In normotensive subjects younger than 50 years, Log-ADPN negatively correlated with LVMI (r = -0.204, p = 0.005); however, Log-ADPN positively correlated with LVMI in ≥50-year-old obese subjects with high arterial stiffness (r = 0.189, p = 0.030). The correlation coefficient between Log-ADPN and LVMI gradually changed from negative to positive with increasing risk factors for LVH. The risk of LVH significantly interacted with the relationship between Log-ADPN and LVMI. In the multivariate analysis, Log-ADPN was associated with LVMI in the subjects at risk of LVH; however, Log-ADPN was either not associated or negatively associated with LVMI in subjects at low risk of LVH.<h4>Conclusion</h4>Adiponectin level and LVMI are negatively associated in subjects at low risk of LVH and are positively associated in subjects at high risk of LVH. Therefore, the relationship between adiponectin and LVMI varies with the risk of LVH.Yonggu LeeBae Keun KimYoung-Hyo LimMi Kyung KimBo Youl ChoiJinho ShinPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e70246 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yonggu Lee Bae Keun Kim Young-Hyo Lim Mi Kyung Kim Bo Youl Choi Jinho Shin The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
description	<h4>Background</h4>Adiponectin directly protects against cardiac remodeling. Despite this beneficial effect, most epidemiological studies have reported a negative relationship between adiponectin level and left ventricular mass index (LVMI). However, a positive relationship has also been reported in subjects at high risk of left ventricular hypertrophy (LVH). Based on these conflicting results, we hypothesized that the relationship between serum adiponectin level and LVMI varies with the risk of LVH.<h4>Methods</h4>A community-based, cross-sectional study was performed on 1414 subjects. LVMI was measured by echocardiography. Log-transformed adiponectin levels (Log-ADPN) were used for the analysis.<h4>Results</h4>Serum adiponectin level had a biphasic distribution (an increase after a decrease) with increasing LVMI. Although Log-ADPN did not correlate with LVMI, Log-ADPN was modestly associated with LVMI in the multivariate analysis (β = 0.079, p = 0.001). The relationship between adiponectin level and LVMI was bidirectional according to the risk of LVH. In normotensive subjects younger than 50 years, Log-ADPN negatively correlated with LVMI (r = -0.204, p = 0.005); however, Log-ADPN positively correlated with LVMI in ≥50-year-old obese subjects with high arterial stiffness (r = 0.189, p = 0.030). The correlation coefficient between Log-ADPN and LVMI gradually changed from negative to positive with increasing risk factors for LVH. The risk of LVH significantly interacted with the relationship between Log-ADPN and LVMI. In the multivariate analysis, Log-ADPN was associated with LVMI in the subjects at risk of LVH; however, Log-ADPN was either not associated or negatively associated with LVMI in subjects at low risk of LVH.<h4>Conclusion</h4>Adiponectin level and LVMI are negatively associated in subjects at low risk of LVH and are positively associated in subjects at high risk of LVH. Therefore, the relationship between adiponectin and LVMI varies with the risk of LVH.
format	article
author	Yonggu Lee Bae Keun Kim Young-Hyo Lim Mi Kyung Kim Bo Youl Choi Jinho Shin
author_facet	Yonggu Lee Bae Keun Kim Young-Hyo Lim Mi Kyung Kim Bo Youl Choi Jinho Shin
author_sort	Yonggu Lee
title	The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
title_short	The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
title_full	The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
title_fullStr	The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
title_full_unstemmed	The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
title_sort	relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/7ac56f84f38a4c3a89fff7b2c1e93ad1
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The relationship between adiponectin and left ventricular mass index varies with the risk of left ventricular hypertrophy.

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