IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA

Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in co...

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Autores principales:	T. I. Vitkina, T. P. Novgorodtseva, E. P. Kalinina, E. G. Lobanova, M. V. Antonyuk
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2019
Materias:	controlled asthma partially controlled asthma th cells cytokines type of t helper immune response clinical and immunological features Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7ac823be2d9b4de7b6ce0c8b91ad2304
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spelling	oai:doaj.org-article:7ac823be2d9b4de7b6ce0c8b91ad23042021-11-18T08:03:48ZIMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA1563-06252313-741X10.15789/1563-0625-2019-3-495-502https://doaj.org/article/7ac823be2d9b4de7b6ce0c8b91ad23042019-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1823https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XDespite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.T. I. VitkinaT. P. NovgorodtsevaE. P. KalininaE. G. LobanovaM. V. AntonyukSPb RAACIarticlecontrolled asthmapartially controlled asthmath cellscytokinestype of t helper immune responseclinical and immunological featuresImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 3, Pp 495-502 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	controlled asthma partially controlled asthma th cells cytokines type of t helper immune response clinical and immunological features Immunologic diseases. Allergy RC581-607
spellingShingle	controlled asthma partially controlled asthma th cells cytokines type of t helper immune response clinical and immunological features Immunologic diseases. Allergy RC581-607 T. I. Vitkina T. P. Novgorodtseva E. P. Kalinina E. G. Lobanova M. V. Antonyuk IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
description	Despite a significant amount of works specifying immune mechanisms of bronchial asthma (BA), different phenotypes observed in this pathology need to be studied. The aim of present study was to analyze functional activity of Th1, Th2 и Th17 lymphocytes, and to determine features of inflammation in controlled and partly controlled asthma.We examined eighty-four BA patients that were divided into 2 groups, depending on the control of symptoms and the clinical course of BA. Group I included 45 patients with controlled BA, whereas group II included 39 patients with partially controlled asthma. The subsets of Th1, Th2, and Th17 lymphocytes were assessed by serum cytokine levels (TNFα, IFNγ, IL-2, IL-4, IL-6, IL-10, IL-17A) using flow cytometry technique.The results of this study were as follows: we have shown a combined T-helper (Th) immune response in asthma patients, with its origin depending on the degree of the disease control. Th2 (62%), Th1/Th2 (20%) and Th1 (18%) types of immune response have been detected in the patients with controlled BA. Th2/Th17 (49%), Th1/Th17 (13%) and Th17 (37%) types of immune response have been identified in the patients with partially controlled BA. It has been shown, that Th1 immune response in patients with controlled asthma is induced by intracellular infection. The formation of the Th1/Th2 phenotype is associated with a site of chronic bacterial infection revealed, and with persistence of viral infection in the body. This phenotype can be used as an indicator of asthma worsening. Further studies in the role of prevalent immune response type in the development of partially controlled BA have shown that activation of Th17 lymphocytes is associated with prolonged course of the disease. Irrespectively of initial phenotype, the development of Th17-dependent immune response seems to result from a durable systemic persistent inflammation.The views on the key role of Th1/Th2 balance in the development of asthma are accomplished by evidence of Th17 lymphocyte involvement into the process, and Th1/Th17, Th2/Th17 phenotypes seem to be the polar features of the disease. Estimation of intensity and phenotype of inflammation in BA will permit a more objective evaluation of the therapy applied, and to choose further management strategies.
format	article
author	T. I. Vitkina T. P. Novgorodtseva E. P. Kalinina E. G. Lobanova M. V. Antonyuk
author_facet	T. I. Vitkina T. P. Novgorodtseva E. P. Kalinina E. G. Lobanova M. V. Antonyuk
author_sort	T. I. Vitkina
title	IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
title_short	IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
title_full	IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
title_fullStr	IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
title_full_unstemmed	IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA
title_sort	immune mechanisms for development of controlled and partially controlled asthma
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/7ac823be2d9b4de7b6ce0c8b91ad2304
work_keys_str_mv	AT tivitkina immunemechanismsfordevelopmentofcontrolledandpartiallycontrolledasthma AT tpnovgorodtseva immunemechanismsfordevelopmentofcontrolledandpartiallycontrolledasthma AT epkalinina immunemechanismsfordevelopmentofcontrolledandpartiallycontrolledasthma AT eglobanova immunemechanismsfordevelopmentofcontrolledandpartiallycontrolledasthma AT mvantonyuk immunemechanismsfordevelopmentofcontrolledandpartiallycontrolledasthma
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IMMUNE MECHANISMS FOR DEVELOPMENT OF CONTROLLED AND PARTIALLY CONTROLLED ASTHMA

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