Prognostic role of neoplastic markers in Takotsubo syndrome

Abstract Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Francesco Santoro, Tecla Zimotti, Adriana Mallardi, Alessandra Leopizzi, Enrica Vitale, Nicola Tarantino, Armando Ferraretti, Antonio Giovanni Solimando, Vito Racanelli, Massimo Iacoviello, Michele Cannone, Matteo Di Biase, Natale Daniele Brunetti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7acc1560c478403998a539ce70eda4af
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7acc1560c478403998a539ce70eda4af
record_format	dspace
spelling	oai:doaj.org-article:7acc1560c478403998a539ce70eda4af2021-12-02T16:45:41ZPrognostic role of neoplastic markers in Takotsubo syndrome10.1038/s41598-021-95990-92045-2322https://doaj.org/article/7acc1560c478403998a539ce70eda4af2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95990-9https://doaj.org/toc/2045-2322Abstract Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects with TTS were enrolled and followed for a median of 3 years. Circulating levels of CA-15.3, CA-19.9 and CEA were evaluated at admission, after 72 h and at discharge. Incidence of MACE during hospitalization and follow-up were recorded. Forty-three (46%) patients experienced MACE during hospitalization. These patients had increased admission levels of CEA (4.3 ± 6.2 vs. 2.2 ± 1.5 ng/mL, p = 0.03). CEA levels were higher in subjects with in-hospital MACE. At long term follow-up, CEA and CA-19.9 levels were associated with increased risk of death (log rank p < 0.01, HR = 5.3, 95% CI 1.9–14.8, HR = 7.8 95% CI 2.4–25.1, respectively, p < 0.01). At multivariable analysis levels higher than median of CEA, CA-19.9 or both were independent predictors of death at long term (Log-Rank p < 0.01). Having both CEA and CA-19.9 levels above median (> 2 ng/mL, > 8 UI/mL respectively) was associated with an increased risk of mortality of 11.8 (95% CI 2.6–52.5, p = 0.001) at follow up. Increased CEA and CA-19.9 serum levels are associated with higher risk of death at long-term follow up in patients with TTS. CEA serum levels are correlated with in-hospital MACE.Francesco SantoroTecla ZimottiAdriana MallardiAlessandra LeopizziEnrica VitaleNicola TarantinoArmando FerrarettiAntonio Giovanni SolimandoVito RacanelliMassimo IacovielloMichele CannoneMatteo Di BiaseNatale Daniele BrunettiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Francesco Santoro Tecla Zimotti Adriana Mallardi Alessandra Leopizzi Enrica Vitale Nicola Tarantino Armando Ferraretti Antonio Giovanni Solimando Vito Racanelli Massimo Iacoviello Michele Cannone Matteo Di Biase Natale Daniele Brunetti Prognostic role of neoplastic markers in Takotsubo syndrome
description	Abstract Takotsubo syndrome (TTS) is an acute heart failure syndrome with significant rates of in and out-of-hospital mayor cardiac adverse events (MACE). To evaluate the possible role of neoplastic biomarkers [CA-15.3, CA-19.9 and Carcinoembryonic Antigen (CEA)] as prognostic marker at short- and long-term follow-up in subjects with TTS. Ninety consecutive subjects with TTS were enrolled and followed for a median of 3 years. Circulating levels of CA-15.3, CA-19.9 and CEA were evaluated at admission, after 72 h and at discharge. Incidence of MACE during hospitalization and follow-up were recorded. Forty-three (46%) patients experienced MACE during hospitalization. These patients had increased admission levels of CEA (4.3 ± 6.2 vs. 2.2 ± 1.5 ng/mL, p = 0.03). CEA levels were higher in subjects with in-hospital MACE. At long term follow-up, CEA and CA-19.9 levels were associated with increased risk of death (log rank p < 0.01, HR = 5.3, 95% CI 1.9–14.8, HR = 7.8 95% CI 2.4–25.1, respectively, p < 0.01). At multivariable analysis levels higher than median of CEA, CA-19.9 or both were independent predictors of death at long term (Log-Rank p < 0.01). Having both CEA and CA-19.9 levels above median (> 2 ng/mL, > 8 UI/mL respectively) was associated with an increased risk of mortality of 11.8 (95% CI 2.6–52.5, p = 0.001) at follow up. Increased CEA and CA-19.9 serum levels are associated with higher risk of death at long-term follow up in patients with TTS. CEA serum levels are correlated with in-hospital MACE.
format	article
author	Francesco Santoro Tecla Zimotti Adriana Mallardi Alessandra Leopizzi Enrica Vitale Nicola Tarantino Armando Ferraretti Antonio Giovanni Solimando Vito Racanelli Massimo Iacoviello Michele Cannone Matteo Di Biase Natale Daniele Brunetti
author_facet	Francesco Santoro Tecla Zimotti Adriana Mallardi Alessandra Leopizzi Enrica Vitale Nicola Tarantino Armando Ferraretti Antonio Giovanni Solimando Vito Racanelli Massimo Iacoviello Michele Cannone Matteo Di Biase Natale Daniele Brunetti
author_sort	Francesco Santoro
title	Prognostic role of neoplastic markers in Takotsubo syndrome
title_short	Prognostic role of neoplastic markers in Takotsubo syndrome
title_full	Prognostic role of neoplastic markers in Takotsubo syndrome
title_fullStr	Prognostic role of neoplastic markers in Takotsubo syndrome
title_full_unstemmed	Prognostic role of neoplastic markers in Takotsubo syndrome
title_sort	prognostic role of neoplastic markers in takotsubo syndrome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7acc1560c478403998a539ce70eda4af
work_keys_str_mv	AT francescosantoro prognosticroleofneoplasticmarkersintakotsubosyndrome AT teclazimotti prognosticroleofneoplasticmarkersintakotsubosyndrome AT adrianamallardi prognosticroleofneoplasticmarkersintakotsubosyndrome AT alessandraleopizzi prognosticroleofneoplasticmarkersintakotsubosyndrome AT enricavitale prognosticroleofneoplasticmarkersintakotsubosyndrome AT nicolatarantino prognosticroleofneoplasticmarkersintakotsubosyndrome AT armandoferraretti prognosticroleofneoplasticmarkersintakotsubosyndrome AT antoniogiovannisolimando prognosticroleofneoplasticmarkersintakotsubosyndrome AT vitoracanelli prognosticroleofneoplasticmarkersintakotsubosyndrome AT massimoiacoviello prognosticroleofneoplasticmarkersintakotsubosyndrome AT michelecannone prognosticroleofneoplasticmarkersintakotsubosyndrome AT matteodibiase prognosticroleofneoplasticmarkersintakotsubosyndrome AT nataledanielebrunetti prognosticroleofneoplasticmarkersintakotsubosyndrome
_version_	1718383461319835648

Prognostic role of neoplastic markers in Takotsubo syndrome

Ejemplares similares