COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey
Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shielding advice and vaccination priorities. We aimed...
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MDPI AG
2021
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oai:doaj.org-article:7acf1c1480b747f9a9d33147a928cf942021-11-11T17:44:43ZCOVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey10.3390/jcm102151252077-0383https://doaj.org/article/7acf1c1480b747f9a9d33147a928cf942021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5125https://doaj.org/toc/2077-0383Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shielding advice and vaccination priorities. We aimed to determine the epidemiological and clinical characteristics of COVID-19 in children with DS. Using data from an international survey obtained from a range of countries and control data from the United States, we compared the prevalence of symptoms and medical complications and risk factors for severe outcomes between DS and non-DS paediatric populations with COVID-19. Hospitalised COVID-19 patients <18 years with DS had a higher incidence of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients without DS <18 years. Older age, obesity, and epilepsy were significant risk factors for hospitalisation among paediatric COVID-19 patients with DS, and age and thyroid disorder were significant risk factors for acute respiratory distress syndrome. Mortality rates were low in all paediatric COVID-19 patients (with and without DS), contrasting with previous findings in adults with DS (who exhibit higher mortality than those without DS). Children with DS are at increased risk for more severe presentations of COVID-19. Efforts should be made to ensure the comprehensive and early detection of COVID-19 in this population and to identify children with DS who present comorbidities that pose a risk for a severe course of COVID-19. Our results emphasize the importance of vaccinating children with DS as soon as they become eligible.David EmesAnke HülsNicole BaumerMara DierssenShiela PuriLauren RussellStephanie L. ShermanAndre StrydomStefania BargagnaAna Cláudia BrandãoAlberto C. S. CostaPatrick T. FeanyBrian Allen ChicoineSujay GhoshAnne-Sophie RebillatGiuseppina SgandurraDiletta ValentiniTilman R. RohrerJohannes LevinMonica Lakhanpaulon behalf of the Trisomy 21 Research Society COVID-19 Initiative Study GroupMDPI AGarticleCOVID-19Down SyndromepaediatricsMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5125, p 5125 (2021) |
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DOAJ |
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EN |
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COVID-19 Down Syndrome paediatrics Medicine R |
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COVID-19 Down Syndrome paediatrics Medicine R David Emes Anke Hüls Nicole Baumer Mara Dierssen Shiela Puri Lauren Russell Stephanie L. Sherman Andre Strydom Stefania Bargagna Ana Cláudia Brandão Alberto C. S. Costa Patrick T. Feany Brian Allen Chicoine Sujay Ghosh Anne-Sophie Rebillat Giuseppina Sgandurra Diletta Valentini Tilman R. Rohrer Johannes Levin Monica Lakhanpaul on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey |
| description |
Adults with Down Syndrome (DS) are at higher risk for severe outcomes of coronavirus disease 2019 (COVID-19) than the general population, but evidence is required to understand the risks for children with DS, which is necessary to inform COVID-19 shielding advice and vaccination priorities. We aimed to determine the epidemiological and clinical characteristics of COVID-19 in children with DS. Using data from an international survey obtained from a range of countries and control data from the United States, we compared the prevalence of symptoms and medical complications and risk factors for severe outcomes between DS and non-DS paediatric populations with COVID-19. Hospitalised COVID-19 patients <18 years with DS had a higher incidence of respiratory symptoms, fever, and several medical complications from COVID-19 than control patients without DS <18 years. Older age, obesity, and epilepsy were significant risk factors for hospitalisation among paediatric COVID-19 patients with DS, and age and thyroid disorder were significant risk factors for acute respiratory distress syndrome. Mortality rates were low in all paediatric COVID-19 patients (with and without DS), contrasting with previous findings in adults with DS (who exhibit higher mortality than those without DS). Children with DS are at increased risk for more severe presentations of COVID-19. Efforts should be made to ensure the comprehensive and early detection of COVID-19 in this population and to identify children with DS who present comorbidities that pose a risk for a severe course of COVID-19. Our results emphasize the importance of vaccinating children with DS as soon as they become eligible. |
| format |
article |
| author |
David Emes Anke Hüls Nicole Baumer Mara Dierssen Shiela Puri Lauren Russell Stephanie L. Sherman Andre Strydom Stefania Bargagna Ana Cláudia Brandão Alberto C. S. Costa Patrick T. Feany Brian Allen Chicoine Sujay Ghosh Anne-Sophie Rebillat Giuseppina Sgandurra Diletta Valentini Tilman R. Rohrer Johannes Levin Monica Lakhanpaul on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group |
| author_facet |
David Emes Anke Hüls Nicole Baumer Mara Dierssen Shiela Puri Lauren Russell Stephanie L. Sherman Andre Strydom Stefania Bargagna Ana Cláudia Brandão Alberto C. S. Costa Patrick T. Feany Brian Allen Chicoine Sujay Ghosh Anne-Sophie Rebillat Giuseppina Sgandurra Diletta Valentini Tilman R. Rohrer Johannes Levin Monica Lakhanpaul on behalf of the Trisomy 21 Research Society COVID-19 Initiative Study Group |
| author_sort |
David Emes |
| title |
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey |
| title_short |
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey |
| title_full |
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey |
| title_fullStr |
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey |
| title_full_unstemmed |
COVID-19 in Children with Down Syndrome: Data from the Trisomy 21 Research Society Survey |
| title_sort |
covid-19 in children with down syndrome: data from the trisomy 21 research society survey |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/7acf1c1480b747f9a9d33147a928cf94 |
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