Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

Matheus Aparecido Dos Santos Ramos,1 Patrícia Bento Da Silva,2 Larissa Spósito,1 Luciani Gaspar De Toledo,1 Bruna Vidal Bonifácio,1 Camila Fernanda Rodero,2 Karen Cristina Dos Santos,2 Marlus Chorilli,2 Taís Maria Bauab1 1São Paulo State Univer...

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Autores principales:	Dos Santos Ramos MA, Da Silva PB, Spósito L, De Toledo LG, Bonifácio BV, Rodero CF, Dos Santos KC, Chorilli M, Bauab TM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Nanotechnology systems microbial biofilms anti-biofilm activity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7ad055453a9d424887fe2af34988098d
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spelling	oai:doaj.org-article:7ad055453a9d424887fe2af34988098d2021-12-02T00:50:00ZNanotechnology-based drug delivery systems for control of microbial biofilms: a review1178-2013https://doaj.org/article/7ad055453a9d424887fe2af34988098d2018-02-01T00:00:00Zhttps://www.dovepress.com/nanotechnology-based-drug-delivery-systems-for-control-of-microbial-bi-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Matheus Aparecido Dos Santos Ramos,1 Patrícia Bento Da Silva,2 Larissa Spósito,1 Luciani Gaspar De Toledo,1 Bruna Vidal Bonifácio,1 Camila Fernanda Rodero,2 Karen Cristina Dos Santos,2 Marlus Chorilli,2 Taís Maria Bauab1 1São Paulo State University (UNESP), School of Pharmaceutical Sciences, Campus Araraquara, Department of Biological Sciences, Araraquara, SP, Brazil; 2São Paulo State University (UNESP), School of Pharmaceutical Sciences, Campus Araraquara, Department of Drugs and Medicines. Araraquara, SP, Brazil Abstract: Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms. Keywords: nanotechnology systems, microbial biofilms, anti-biofilm activityDos Santos Ramos MADa Silva PBSpósito LDe Toledo LGBonifácio BVRodero CFDos Santos KCChorilli MBauab TMDove Medical PressarticleNanotechnology systemsmicrobial biofilmsanti-biofilm activityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 1179-1213 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Nanotechnology systems microbial biofilms anti-biofilm activity Medicine (General) R5-920
spellingShingle	Nanotechnology systems microbial biofilms anti-biofilm activity Medicine (General) R5-920 Dos Santos Ramos MA Da Silva PB Spósito L De Toledo LG Bonifácio BV Rodero CF Dos Santos KC Chorilli M Bauab TM Nanotechnology-based drug delivery systems for control of microbial biofilms: a review
description	Matheus Aparecido Dos Santos Ramos,1 Patrícia Bento Da Silva,2 Larissa Spósito,1 Luciani Gaspar De Toledo,1 Bruna Vidal Bonifácio,1 Camila Fernanda Rodero,2 Karen Cristina Dos Santos,2 Marlus Chorilli,2 Taís Maria Bauab1 1São Paulo State University (UNESP), School of Pharmaceutical Sciences, Campus Araraquara, Department of Biological Sciences, Araraquara, SP, Brazil; 2São Paulo State University (UNESP), School of Pharmaceutical Sciences, Campus Araraquara, Department of Drugs and Medicines. Araraquara, SP, Brazil Abstract: Since the dawn of civilization, it has been understood that pathogenic microorganisms cause infectious conditions in humans, which at times, may prove fatal. Among the different virulent properties of microorganisms is their ability to form biofilms, which has been directly related to the development of chronic infections with increased disease severity. A problem in the elimination of such complex structures (biofilms) is resistance to the drugs that are currently used in clinical practice, and therefore, it becomes imperative to search for new compounds that have anti-biofilm activity. In this context, nanotechnology provides secure platforms for targeted delivery of drugs to treat numerous microbial infections that are caused by biofilms. Among the many applications of such nanotechnology-based drug delivery systems is their ability to enhance the bioactive potential of therapeutic agents. The present study reports the use of important nanoparticles, such as liposomes, microemulsions, cyclodextrins, solid lipid nanoparticles, polymeric nanoparticles, and metallic nanoparticles, in controlling microbial biofilms by targeted drug delivery. Such utilization of these nanosystems has led to a better understanding of their applications and their role in combating biofilms. Keywords: nanotechnology systems, microbial biofilms, anti-biofilm activity
format	article
author	Dos Santos Ramos MA Da Silva PB Spósito L De Toledo LG Bonifácio BV Rodero CF Dos Santos KC Chorilli M Bauab TM
author_facet	Dos Santos Ramos MA Da Silva PB Spósito L De Toledo LG Bonifácio BV Rodero CF Dos Santos KC Chorilli M Bauab TM
author_sort	Dos Santos Ramos MA
title	Nanotechnology-based drug delivery systems for control of microbial biofilms: a review
title_short	Nanotechnology-based drug delivery systems for control of microbial biofilms: a review
title_full	Nanotechnology-based drug delivery systems for control of microbial biofilms: a review
title_fullStr	Nanotechnology-based drug delivery systems for control of microbial biofilms: a review
title_full_unstemmed	Nanotechnology-based drug delivery systems for control of microbial biofilms: a review
title_sort	nanotechnology-based drug delivery systems for control of microbial biofilms: a review
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/7ad055453a9d424887fe2af34988098d
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Nanotechnology-based drug delivery systems for control of microbial biofilms: a review

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