Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis

Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, W...

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Autores principales:	Zhang CH, Su XL, Liu YY, Lin L, Wang YC, Li XD, Zhang JZ, Wei W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e
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spelling	oai:doaj.org-article:7ad0ea1b741846ce90d8a8697367ea0e2021-12-02T16:15:13ZStudy on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis1178-7031https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e2021-07-01T00:00:00Zhttps://www.dovepress.com/study-on-the-effect-of-antiplatelet-and-gastric-mucosal-protection-of--peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr@163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicineZhang CHSu XLLiu YYLin LWang YCLi XDZhang JZWei WDove Medical Pressarticlesupplementing qi and hemostasis herbsproton pump inhibitionantiplatelet effectgastric mucosal protectiontraditional chinese medicinetcmPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 3023-3037 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	supplementing qi and hemostasis herbs proton pump inhibition antiplatelet effect gastric mucosal protection traditional chinese medicine tcm Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Zhang CH Su XL Liu YY Lin L Wang YC Li XD Zhang JZ Wei W Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
description	Chen-Hao Zhang,1,&ast; Xiao-Lan Su,2,&ast; Yi-Ying Liu,1 Long Lin,1 Yin-Chun Wang,1 Xiao-Dong Li,1 Jin-Ze Zhang,1 Wei Wei2 1Department of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China; 2Department of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chen-Hao ZhangDepartment of Emergency, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, 100102, People’s Republic of ChinaTel +86 136 7139 3316Email zhangch_dr@163.comWei WeiDepartment of Gastroenterology, Wangjing Hospital of China Academy of Chinese Medical Sciences, No. 6 of Wangjing Zhonghuan South Street, Chaoyang District, Beijing, 100102, People’s Republic of ChinaTel +86 13601233816Email weiweigrt@163.comBackground: To investigate the effects of Chinese herbal medicine in tonifying qi and attaining hemostasis caused by the metabolism of the drug clopidogrel and as a result of platelet and gastric mucosa injury in an ischemia-reperfusion rat model.Methods: A pharmacokinetic model was established to record the drug metabolism parameters of clopidogrel metabolites. Then, absorption of the drug was compared with approaches using the traditional Chinese medicine (TCM) approach of tonifying qi and establishing hemostasis, to using the drug pantoprazole and applying these approaches in combination with clopidogrel. Intragastric administration was performed, and all indicators were tested.Results: The area under the curve (AUC; 0–T, 300.342 ± 35.832 mg/L&ast; h; AUC 0–∞, 320.462 ± 40.213 mg/L&ast; h), the plasma peak concentration (30.622 ± 9.917 mg/L&ast;), and the peak time and half-life (7.954 ± 1.121 h) in the clopidogrel and the TCM groups were higher than those in the clopidogrel and pantoprazole groups. In terms of antiplatelet aggregation, compared with model group, the platelet aggregation rate induced by arachidonic acid (AA) and adenosine diphosphate (ADP) was significantly decreased by the TCM approach of tonifying qi and stopping bleeding (p < 0.05). The ADP, thromboxane A2, GPII B/Pa-A, CD62P and platelet factor 4 content in the TCM yiqi decoction and hemostasis approach were significantly decreased (p < 0.01). Compared with the clopidogrel group, the gastrin and motilin in the serum, the cyclooxygenase (COX)-1 and prostaglandin E2 in gastric tissue, and expression of vascular endothelial growth factor messenger ribonucleic acid in the serum were all significantly increased using TCM approach to protect against gastric mucosal injury (p < 0.05).Conclusion: TCM invigorating qi and hemostasis has an inhibitory effect on platelet activation. It can reduce the local inflammatory reaction at the same time as protecting gastric mucosa.Keywords: supplementing qi and hemostasis herbs, proton pump inhibition, antiplatelet effect, gastric mucosal protection, traditional Chinese medicine
format	article
author	Zhang CH Su XL Liu YY Lin L Wang YC Li XD Zhang JZ Wei W
author_facet	Zhang CH Su XL Liu YY Lin L Wang YC Li XD Zhang JZ Wei W
author_sort	Zhang CH
title	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
title_short	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
title_full	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
title_fullStr	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
title_full_unstemmed	Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis
title_sort	study on the effect of antiplatelet and gastric mucosal protection of traditional chinese medicine invigorating qi and hemostasis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/7ad0ea1b741846ce90d8a8697367ea0e
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Study on the Effect of Antiplatelet and Gastric Mucosal Protection of Traditional Chinese Medicine Invigorating Qi and Hemostasis

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