Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.
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Nature Portfolio
2019
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oai:doaj.org-article:7ad18a0cfcb742e09b108e2916ba4cfd2021-12-02T14:38:46ZLysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export10.1038/s41467-019-11425-02041-1723https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11425-0https://doaj.org/toc/2041-1723Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport.Saskia HeybrockKristiina KanervaYing MengChris IngAnna LiangZi-Jian XiongXialian WengYoung Ah KimRichard CollinsWilliam TrimbleRégis PomèsGilbert G. PrivéWim AnnaertMichael SchwakeJoerg HeerenRenate Lüllmann-RauchSergio GrinsteinElina IkonenPaul SaftigDante NeculaiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Saskia Heybrock Kristiina Kanerva Ying Meng Chris Ing Anna Liang Zi-Jian Xiong Xialian Weng Young Ah Kim Richard Collins William Trimble Régis Pomès Gilbert G. Privé Wim Annaert Michael Schwake Joerg Heeren Renate Lüllmann-Rauch Sergio Grinstein Elina Ikonen Paul Saftig Dante Neculai Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export |
| description |
Cholesterol transport is tightly regulated in the cell and in lysosomes is regulated by NPC1/2. Here, Heybrock et al. use molecular modeling, knockout mice and cell based studies to show that LIMP-2 also mediates lysosomal cholesterol transport. |
| format |
article |
| author |
Saskia Heybrock Kristiina Kanerva Ying Meng Chris Ing Anna Liang Zi-Jian Xiong Xialian Weng Young Ah Kim Richard Collins William Trimble Régis Pomès Gilbert G. Privé Wim Annaert Michael Schwake Joerg Heeren Renate Lüllmann-Rauch Sergio Grinstein Elina Ikonen Paul Saftig Dante Neculai |
| author_facet |
Saskia Heybrock Kristiina Kanerva Ying Meng Chris Ing Anna Liang Zi-Jian Xiong Xialian Weng Young Ah Kim Richard Collins William Trimble Régis Pomès Gilbert G. Privé Wim Annaert Michael Schwake Joerg Heeren Renate Lüllmann-Rauch Sergio Grinstein Elina Ikonen Paul Saftig Dante Neculai |
| author_sort |
Saskia Heybrock |
| title |
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export |
| title_short |
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export |
| title_full |
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export |
| title_fullStr |
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export |
| title_full_unstemmed |
Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export |
| title_sort |
lysosomal integral membrane protein-2 (limp-2/scarb2) is involved in lysosomal cholesterol export |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/7ad18a0cfcb742e09b108e2916ba4cfd |
| work_keys_str_mv |
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