Changes in Cardiac Metabolism in Prediabetes

In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac function that precedes the onset of cardiac failure, and it occurs al...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Vera H. W. de Wit-Verheggen, Tineke van de Weijer
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cardiac metabolism prediabetes mitochondrial function cardiac function Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7adc2f89c3954565ab4631b1fd58e54d
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7adc2f89c3954565ab4631b1fd58e54d
record_format	dspace
spelling	oai:doaj.org-article:7adc2f89c3954565ab4631b1fd58e54d2021-11-25T16:53:45ZChanges in Cardiac Metabolism in Prediabetes10.3390/biom111116802218-273Xhttps://doaj.org/article/7adc2f89c3954565ab4631b1fd58e54d2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1680https://doaj.org/toc/2218-273XIn type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac function that precedes the onset of cardiac failure, and it occurs already in the prediabetic state. It is clear that these changes are closely linked to alterations in cardiac metabolism; however, the exact etiology is unknown. In this narrative review, we provide an overview of the early cardiac changes in fatty acid and glucose metabolism in prediabetes and its consequences on cardiac function. A better understanding of the relationship between metabolism, mitochondrial function, and cardiac function will lead to insights into the etiology of the declined cardiac function in prediabetes.Vera H. W. de Wit-VerheggenTineke van de WeijerMDPI AGarticlecardiac metabolismprediabetesmitochondrial functioncardiac functionMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1680, p 1680 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiac metabolism prediabetes mitochondrial function cardiac function Microbiology QR1-502
spellingShingle	cardiac metabolism prediabetes mitochondrial function cardiac function Microbiology QR1-502 Vera H. W. de Wit-Verheggen Tineke van de Weijer Changes in Cardiac Metabolism in Prediabetes
description	In type 2 diabetes mellitus (T2DM), there is an increased prevalence of cardiovascular disease (CVD), even when corrected for atherosclerosis and other CVD risk factors. Diastolic dysfunction is one of the early changes in cardiac function that precedes the onset of cardiac failure, and it occurs already in the prediabetic state. It is clear that these changes are closely linked to alterations in cardiac metabolism; however, the exact etiology is unknown. In this narrative review, we provide an overview of the early cardiac changes in fatty acid and glucose metabolism in prediabetes and its consequences on cardiac function. A better understanding of the relationship between metabolism, mitochondrial function, and cardiac function will lead to insights into the etiology of the declined cardiac function in prediabetes.
format	article
author	Vera H. W. de Wit-Verheggen Tineke van de Weijer
author_facet	Vera H. W. de Wit-Verheggen Tineke van de Weijer
author_sort	Vera H. W. de Wit-Verheggen
title	Changes in Cardiac Metabolism in Prediabetes
title_short	Changes in Cardiac Metabolism in Prediabetes
title_full	Changes in Cardiac Metabolism in Prediabetes
title_fullStr	Changes in Cardiac Metabolism in Prediabetes
title_full_unstemmed	Changes in Cardiac Metabolism in Prediabetes
title_sort	changes in cardiac metabolism in prediabetes
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7adc2f89c3954565ab4631b1fd58e54d
work_keys_str_mv	AT verahwdewitverheggen changesincardiacmetabolisminprediabetes AT tinekevandeweijer changesincardiacmetabolisminprediabetes
_version_	1718412905147269120

Changes in Cardiac Metabolism in Prediabetes

Ejemplares similares