MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor

Abstract Diabetes is an inflammatory disease. Inflammation plays an important role in islet functions. However, the exact mechanisms by which inflammation affects islet functions remain unclear. In this study, we investigated the regulatory effects of miR-30a on inflammation and islet functions. The...

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Autores principales:	Xin Jiang, Chenke Xu, Fan Lei, Meijian Liao, Wei Wang, Naihan Xu, Yaou Zhang, Weidong Xie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7adcc571679b49e280122f791daa1ae1
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spelling	oai:doaj.org-article:7adcc571679b49e280122f791daa1ae12021-12-02T11:40:51ZMiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor10.1038/s41598-017-05560-12045-2322https://doaj.org/article/7adcc571679b49e280122f791daa1ae12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05560-1https://doaj.org/toc/2045-2322Abstract Diabetes is an inflammatory disease. Inflammation plays an important role in islet functions. However, the exact mechanisms by which inflammation affects islet functions remain unclear. In this study, we investigated the regulatory effects of miR-30a on inflammation and islet functions. The results indicate that miR-30a serves as an inflammation-resolving buffer factor by targeting interleukin 1a (IL-1α) in immune cells and in islet cells, which might play an important role in inflammation homeostasis. miR-30a ameliorates islet functions in an inflammatory micro-environment by targeting the IL-1α/nuclear factor kappa B (NFKB) p65 subunit (p65)/p62 (SQSTM1)/insulin axis, which can be developed into a novel antidiabetic approach. miR-30a serves as a promising inflammation-response biomarker in inflammatory diseases and is possibly activated by the toll-like receptor 4 (TLR4)/IL-1α/NFKB pathways. However, the exact molecular mechanisms by which miR-30a regulates inflammation and islet functions as well as the potential applications in transitional medicine require further elucidation.Xin JiangChenke XuFan LeiMeijian LiaoWei WangNaihan XuYaou ZhangWeidong XieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xin Jiang Chenke Xu Fan Lei Meijian Liao Wei Wang Naihan Xu Yaou Zhang Weidong Xie MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
description	Abstract Diabetes is an inflammatory disease. Inflammation plays an important role in islet functions. However, the exact mechanisms by which inflammation affects islet functions remain unclear. In this study, we investigated the regulatory effects of miR-30a on inflammation and islet functions. The results indicate that miR-30a serves as an inflammation-resolving buffer factor by targeting interleukin 1a (IL-1α) in immune cells and in islet cells, which might play an important role in inflammation homeostasis. miR-30a ameliorates islet functions in an inflammatory micro-environment by targeting the IL-1α/nuclear factor kappa B (NFKB) p65 subunit (p65)/p62 (SQSTM1)/insulin axis, which can be developed into a novel antidiabetic approach. miR-30a serves as a promising inflammation-response biomarker in inflammatory diseases and is possibly activated by the toll-like receptor 4 (TLR4)/IL-1α/NFKB pathways. However, the exact molecular mechanisms by which miR-30a regulates inflammation and islet functions as well as the potential applications in transitional medicine require further elucidation.
format	article
author	Xin Jiang Chenke Xu Fan Lei Meijian Liao Wei Wang Naihan Xu Yaou Zhang Weidong Xie
author_facet	Xin Jiang Chenke Xu Fan Lei Meijian Liao Wei Wang Naihan Xu Yaou Zhang Weidong Xie
author_sort	Xin Jiang
title	MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
title_short	MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
title_full	MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
title_fullStr	MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
title_full_unstemmed	MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor
title_sort	mir-30a targets il-1α and regulates islet functions as an inflammation buffer and response factor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7adcc571679b49e280122f791daa1ae1
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MiR-30a targets IL-1α and regulates islet functions as an inflammation buffer and response factor

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