MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.

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Autores principales:	Yi Wang, Wu Luo, Jibo Han, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ae086d521474d0c9dfe695bbcf6dabd
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spelling	oai:doaj.org-article:7ae086d521474d0c9dfe695bbcf6dabd2021-12-02T14:42:48ZMD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy10.1038/s41467-020-15978-32041-1723https://doaj.org/article/7ae086d521474d0c9dfe695bbcf6dabd2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15978-3https://doaj.org/toc/2041-1723The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.Yi WangWu LuoJibo HanZia A. KhanQilu FangYiyi JinXuemei ChenYali ZhangMeihong WangJianchang QianWeijian HuangHazel LumGaojun WuGuang LiangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yi Wang Wu Luo Jibo Han Zia A. Khan Qilu Fang Yiyi Jin Xuemei Chen Yali Zhang Meihong Wang Jianchang Qian Weijian Huang Hazel Lum Gaojun Wu Guang Liang MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy
description	The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.
format	article
author	Yi Wang Wu Luo Jibo Han Zia A. Khan Qilu Fang Yiyi Jin Xuemei Chen Yali Zhang Meihong Wang Jianchang Qian Weijian Huang Hazel Lum Gaojun Wu Guang Liang
author_facet	Yi Wang Wu Luo Jibo Han Zia A. Khan Qilu Fang Yiyi Jin Xuemei Chen Yali Zhang Meihong Wang Jianchang Qian Weijian Huang Hazel Lum Gaojun Wu Guang Liang
author_sort	Yi Wang
title	MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy
title_short	MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy
title_full	MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy
title_fullStr	MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy
title_full_unstemmed	MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy
title_sort	md2 activation by direct age interaction drives inflammatory diabetic cardiomyopathy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7ae086d521474d0c9dfe695bbcf6dabd
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MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

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