MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

MD2 activation by direct AGE interaction drives inflammatory diabetic cardiomyopathy

The mechanisms underlying cardiac inflammation in diabetic cardiomyopathy are incompletely understood. Here the authors show that advanced glycation end products bind to the TLR4 co-receptor MD2 initiating pro-inflammatory pathways.

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Detalles Bibliográficos
Autores principales: Yi Wang, Wu Luo, Jibo Han, Zia A. Khan, Qilu Fang, Yiyi Jin, Xuemei Chen, Yali Zhang, Meihong Wang, Jianchang Qian, Weijian Huang, Hazel Lum, Gaojun Wu, Guang Liang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/7ae086d521474d0c9dfe695bbcf6dabd
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