Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis similar to culture with mucus in vitro.
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Nature Portfolio
2021
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oai:doaj.org-article:7ae3dc520a6942e4b406f935ccf6c8eb2021-11-14T12:36:50ZEpigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease10.1038/s41467-021-26777-92041-1723https://doaj.org/article/7ae3dc520a6942e4b406f935ccf6c8eb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26777-9https://doaj.org/toc/2041-1723Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis similar to culture with mucus in vitro.Joschka HeyMichelle PaulsenReka TothDieter WeichenhanSimone ButzJolanthe SchatternyReinhard LiebersPavlo LutsikChristoph PlassMarcus A. MallNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q |
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Science Q Joschka Hey Michelle Paulsen Reka Toth Dieter Weichenhan Simone Butz Jolanthe Schatterny Reinhard Liebers Pavlo Lutsik Christoph Plass Marcus A. Mall Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
description |
Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis similar to culture with mucus in vitro. |
format |
article |
author |
Joschka Hey Michelle Paulsen Reka Toth Dieter Weichenhan Simone Butz Jolanthe Schatterny Reinhard Liebers Pavlo Lutsik Christoph Plass Marcus A. Mall |
author_facet |
Joschka Hey Michelle Paulsen Reka Toth Dieter Weichenhan Simone Butz Jolanthe Schatterny Reinhard Liebers Pavlo Lutsik Christoph Plass Marcus A. Mall |
author_sort |
Joschka Hey |
title |
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
title_short |
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
title_full |
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
title_fullStr |
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
title_full_unstemmed |
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
title_sort |
epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/7ae3dc520a6942e4b406f935ccf6c8eb |
work_keys_str_mv |
AT joschkahey epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT michellepaulsen epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT rekatoth epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT dieterweichenhan epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT simonebutz epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT jolantheschatterny epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT reinhardliebers epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT pavlolutsik epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT christophplass epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease AT marcusamall epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease |
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