Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis similar to culture with mucus in vitro.

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Autores principales: Joschka Hey, Michelle Paulsen, Reka Toth, Dieter Weichenhan, Simone Butz, Jolanthe Schatterny, Reinhard Liebers, Pavlo Lutsik, Christoph Plass, Marcus A. Mall
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7ae3dc520a6942e4b406f935ccf6c8eb
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spelling oai:doaj.org-article:7ae3dc520a6942e4b406f935ccf6c8eb2021-11-14T12:36:50ZEpigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease10.1038/s41467-021-26777-92041-1723https://doaj.org/article/7ae3dc520a6942e4b406f935ccf6c8eb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26777-9https://doaj.org/toc/2041-1723Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis similar to culture with mucus in vitro.Joschka HeyMichelle PaulsenReka TothDieter WeichenhanSimone ButzJolanthe SchatternyReinhard LiebersPavlo LutsikChristoph PlassMarcus A. MallNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Joschka Hey
Michelle Paulsen
Reka Toth
Dieter Weichenhan
Simone Butz
Jolanthe Schatterny
Reinhard Liebers
Pavlo Lutsik
Christoph Plass
Marcus A. Mall
Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
description Muco-obstructive lung diseases are characterised by airway macrophage (AM) populations which may have epigenetic changes. Here using a mouse model the authors show epigenetic alteration of AMs with changes in LPS response, phagocytosis and efferocytosis similar to culture with mucus in vitro.
format article
author Joschka Hey
Michelle Paulsen
Reka Toth
Dieter Weichenhan
Simone Butz
Jolanthe Schatterny
Reinhard Liebers
Pavlo Lutsik
Christoph Plass
Marcus A. Mall
author_facet Joschka Hey
Michelle Paulsen
Reka Toth
Dieter Weichenhan
Simone Butz
Jolanthe Schatterny
Reinhard Liebers
Pavlo Lutsik
Christoph Plass
Marcus A. Mall
author_sort Joschka Hey
title Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
title_short Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
title_full Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
title_fullStr Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
title_full_unstemmed Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
title_sort epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7ae3dc520a6942e4b406f935ccf6c8eb
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AT rekatoth epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease
AT dieterweichenhan epigeneticreprogrammingofairwaymacrophagespromotespolarizationandinflammationinmucoobstructivelungdisease
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