Catastrophic disassembly of actin filaments via Mical-mediated oxidation

MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of i...

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Autores principales:	Elena E. Grintsevich, Peng Ge, Michael R. Sawaya, Hunkar Gizem Yesilyurt, Jonathan R. Terman, Z. Hong Zhou, Emil Reisler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ae7d1bd50ae4f3380c5ffcce5f2ab7d
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spelling	oai:doaj.org-article:7ae7d1bd50ae4f3380c5ffcce5f2ab7d2021-12-02T15:39:03ZCatastrophic disassembly of actin filaments via Mical-mediated oxidation10.1038/s41467-017-02357-82041-1723https://doaj.org/article/7ae7d1bd50ae4f3380c5ffcce5f2ab7d2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02357-8https://doaj.org/toc/2041-1723MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate.Elena E. GrintsevichPeng GeMichael R. SawayaHunkar Gizem YesilyurtJonathan R. TermanZ. Hong ZhouEmil ReislerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elena E. Grintsevich Peng Ge Michael R. Sawaya Hunkar Gizem Yesilyurt Jonathan R. Terman Z. Hong Zhou Emil Reisler Catastrophic disassembly of actin filaments via Mical-mediated oxidation
description	MICAL Redox enzymes post-translationally modify F-actin to promote its cellular destabilization. Here, the authors present a 3.9Å cryoEM structure of Mical-oxidized F-actin, showing its nucleotide-state dependent dynamic instability and susceptibility to cofilin-induced severing in the presence of inorganic phosphate.
format	article
author	Elena E. Grintsevich Peng Ge Michael R. Sawaya Hunkar Gizem Yesilyurt Jonathan R. Terman Z. Hong Zhou Emil Reisler
author_facet	Elena E. Grintsevich Peng Ge Michael R. Sawaya Hunkar Gizem Yesilyurt Jonathan R. Terman Z. Hong Zhou Emil Reisler
author_sort	Elena E. Grintsevich
title	Catastrophic disassembly of actin filaments via Mical-mediated oxidation
title_short	Catastrophic disassembly of actin filaments via Mical-mediated oxidation
title_full	Catastrophic disassembly of actin filaments via Mical-mediated oxidation
title_fullStr	Catastrophic disassembly of actin filaments via Mical-mediated oxidation
title_full_unstemmed	Catastrophic disassembly of actin filaments via Mical-mediated oxidation
title_sort	catastrophic disassembly of actin filaments via mical-mediated oxidation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7ae7d1bd50ae4f3380c5ffcce5f2ab7d
work_keys_str_mv	AT elenaegrintsevich catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation AT pengge catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation AT michaelrsawaya catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation AT hunkargizemyesilyurt catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation AT jonathanrterman catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation AT zhongzhou catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation AT emilreisler catastrophicdisassemblyofactinfilamentsviamicalmediatedoxidation
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Catastrophic disassembly of actin filaments via Mical-mediated oxidation

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