The tumor therapy landscape of synthetic lethality

Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http://www.slkg.net) to explore the comprehensive t...

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Autores principales:	Biyu Zhang, Chen Tang, Yanli Yao, Xiaohan Chen, Chi Zhou, Zhiting Wei, Feiyang Xing, Lan Chen, Xiang Cai, Zhiyuan Zhang, Shuyang Sun, Qi Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7ae8b76351274d949642eef25f3ad42c
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spelling	oai:doaj.org-article:7ae8b76351274d949642eef25f3ad42c2021-12-02T13:33:09ZThe tumor therapy landscape of synthetic lethality10.1038/s41467-021-21544-22041-1723https://doaj.org/article/7ae8b76351274d949642eef25f3ad42c2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21544-2https://doaj.org/toc/2041-1723Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http://www.slkg.net) to explore the comprehensive tumor therapy landscape and uncover cancer-specific susceptibilities based on the principle of synthetic lethality.Biyu ZhangChen TangYanli YaoXiaohan ChenChi ZhouZhiting WeiFeiyang XingLan ChenXiang CaiZhiyuan ZhangShuyang SunQi LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Biyu Zhang Chen Tang Yanli Yao Xiaohan Chen Chi Zhou Zhiting Wei Feiyang Xing Lan Chen Xiang Cai Zhiyuan Zhang Shuyang Sun Qi Liu The tumor therapy landscape of synthetic lethality
description	Various methods have been proposed to identify synthetic lethality interactions, but selective treatment opportunities for various tumors have not yet been explored. Here, the authors develop the Synthetic Lethality Knowledge Graph webserver (SLKG, http://www.slkg.net) to explore the comprehensive tumor therapy landscape and uncover cancer-specific susceptibilities based on the principle of synthetic lethality.
format	article
author	Biyu Zhang Chen Tang Yanli Yao Xiaohan Chen Chi Zhou Zhiting Wei Feiyang Xing Lan Chen Xiang Cai Zhiyuan Zhang Shuyang Sun Qi Liu
author_facet	Biyu Zhang Chen Tang Yanli Yao Xiaohan Chen Chi Zhou Zhiting Wei Feiyang Xing Lan Chen Xiang Cai Zhiyuan Zhang Shuyang Sun Qi Liu
author_sort	Biyu Zhang
title	The tumor therapy landscape of synthetic lethality
title_short	The tumor therapy landscape of synthetic lethality
title_full	The tumor therapy landscape of synthetic lethality
title_fullStr	The tumor therapy landscape of synthetic lethality
title_full_unstemmed	The tumor therapy landscape of synthetic lethality
title_sort	tumor therapy landscape of synthetic lethality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7ae8b76351274d949642eef25f3ad42c
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The tumor therapy landscape of synthetic lethality

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