Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

Oleanolic acid (OA, 3 β - hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic triterpenoid present in many plants. As a new framework for development of semi synthetic triterpenoids, OA is of great significance in the discovery of anticancer drugs. Some of these derivatives, such as CDDO (2-cy...

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Autores principales:	Zhong-Yuan Tang, Yang Li, Yu-Ting Tang, Xiao-Dong Ma, Ze-Yao Tang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Oleanolic acid Derivatives Apoptotic pathways Angiogenesis Metastasis Systematic -analysis review Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7aef5f3ef6ec4b2bac39d66f5a2ffa09
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spelling	oai:doaj.org-article:7aef5f3ef6ec4b2bac39d66f5a2ffa092021-11-18T04:43:35ZAnticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action0753-332210.1016/j.biopha.2021.112397https://doaj.org/article/7aef5f3ef6ec4b2bac39d66f5a2ffa092022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221011835https://doaj.org/toc/0753-3322Oleanolic acid (OA, 3 β - hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic triterpenoid present in many plants. As a new framework for development of semi synthetic triterpenoids, OA is of great significance in the discovery of anticancer drugs. Some of these derivatives, such as CDDO (2-cyano-3,12-dioxooleana-1, 9 (11)-dien-28-oic acid) have been verified in clinical trials, while other derivatives studied previously, such as SZC014, SZC015 and SZC017 (OA derivatives respectively), are also candidate drugs for cancer treatment. This paper reviews the preclinical studies, literature evidence, target analysis and anticancer mechanism of OA and its derivatives. The mechanism of action of its derivatives mainly includes anti-cancer cell proliferation, inducing tumor cell apoptosis, inducing autophagy, regulating cell cycle regulatory proteins, inhibiting vascular endothelial growth, anti angiogenesis, inhibiting tumor cell migration and invasion. In recent years, the molecular mechanism of OA and its derivatives has been elucidated. These effects seem to be mediated by the alterations in a variety of signaling pathways induced by OA and its derivatives. In conclusion, OA and its derivatives are considered as important candidate drugs for the treatment of cancer, indicating that OA and its derivatives have the potential to be used as anticancer drugs in practice.Zhong-Yuan TangYang LiYu-Ting TangXiao-Dong MaZe-Yao TangElsevierarticleOleanolic acidDerivativesApoptotic pathwaysAngiogenesisMetastasisSystematic -analysis reviewTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112397- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oleanolic acid Derivatives Apoptotic pathways Angiogenesis Metastasis Systematic -analysis review Therapeutics. Pharmacology RM1-950
spellingShingle	Oleanolic acid Derivatives Apoptotic pathways Angiogenesis Metastasis Systematic -analysis review Therapeutics. Pharmacology RM1-950 Zhong-Yuan Tang Yang Li Yu-Ting Tang Xiao-Dong Ma Ze-Yao Tang Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
description	Oleanolic acid (OA, 3 β - hydroxyoleanolic acid-12-en-28-oic acid) is a pentacyclic triterpenoid present in many plants. As a new framework for development of semi synthetic triterpenoids, OA is of great significance in the discovery of anticancer drugs. Some of these derivatives, such as CDDO (2-cyano-3,12-dioxooleana-1, 9 (11)-dien-28-oic acid) have been verified in clinical trials, while other derivatives studied previously, such as SZC014, SZC015 and SZC017 (OA derivatives respectively), are also candidate drugs for cancer treatment. This paper reviews the preclinical studies, literature evidence, target analysis and anticancer mechanism of OA and its derivatives. The mechanism of action of its derivatives mainly includes anti-cancer cell proliferation, inducing tumor cell apoptosis, inducing autophagy, regulating cell cycle regulatory proteins, inhibiting vascular endothelial growth, anti angiogenesis, inhibiting tumor cell migration and invasion. In recent years, the molecular mechanism of OA and its derivatives has been elucidated. These effects seem to be mediated by the alterations in a variety of signaling pathways induced by OA and its derivatives. In conclusion, OA and its derivatives are considered as important candidate drugs for the treatment of cancer, indicating that OA and its derivatives have the potential to be used as anticancer drugs in practice.
format	article
author	Zhong-Yuan Tang Yang Li Yu-Ting Tang Xiao-Dong Ma Ze-Yao Tang
author_facet	Zhong-Yuan Tang Yang Li Yu-Ting Tang Xiao-Dong Ma Ze-Yao Tang
author_sort	Zhong-Yuan Tang
title	Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
title_short	Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
title_full	Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
title_fullStr	Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
title_full_unstemmed	Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action
title_sort	anticancer activity of oleanolic acid and its derivatives: recent advances in evidence, target profiling and mechanisms of action
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/7aef5f3ef6ec4b2bac39d66f5a2ffa09
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Anticancer activity of oleanolic acid and its derivatives: Recent advances in evidence, target profiling and mechanisms of action

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