Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing

Abstract Physical or perceived (i.e. loneliness) social isolation is increasing in Western cultures. Unfortunately, social isolation is associated with a range of negative physical and mental health outcomes, including increased incidence of obesity and smoking. Here we monitored the impact of socia...

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Autores principales:	Natalie A. Mastrogiovanni, Alice K. Wheeler, Kelly J. Clemens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7af1a185de7f429ba2a9b5c316985bf2
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spelling	oai:doaj.org-article:7af1a185de7f429ba2a9b5c316985bf22021-12-02T13:23:58ZSocial isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing10.1038/s41598-021-81966-22045-2322https://doaj.org/article/7af1a185de7f429ba2a9b5c316985bf22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81966-2https://doaj.org/toc/2045-2322Abstract Physical or perceived (i.e. loneliness) social isolation is increasing in Western cultures. Unfortunately, social isolation is associated with a range of negative physical and mental health outcomes, including increased incidence of obesity and smoking. Here we monitored the impact of social isolation on a range of physical measures, and then tested whether social isolation in adult rats changes how reward-related stimuli motivate sucrose- or nicotine-seeking. Socially isolated rats showed elevated baseline CORT, gained significantly less weight across the study, were more active in response to a novel or familiar environment. Isolated rats also acquired nose-poking for a food pellet more rapidly, and showed increased susceptibility to cue-, but not reward-induced reinstatement. Notably, these effects are partially mitigated by a return to group housing, suggesting that they are not necessarily permanent, and that a return to a social setting can quickly reverse any deficits or changes associated with social isolation. This study advances our understanding of altered reward-processing in socially isolated individuals and reiterates the importance of socialisation in the treatment of disorders such as overeating and addiction.Natalie A. MastrogiovanniAlice K. WheelerKelly J. ClemensNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Natalie A. Mastrogiovanni Alice K. Wheeler Kelly J. Clemens Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
description	Abstract Physical or perceived (i.e. loneliness) social isolation is increasing in Western cultures. Unfortunately, social isolation is associated with a range of negative physical and mental health outcomes, including increased incidence of obesity and smoking. Here we monitored the impact of social isolation on a range of physical measures, and then tested whether social isolation in adult rats changes how reward-related stimuli motivate sucrose- or nicotine-seeking. Socially isolated rats showed elevated baseline CORT, gained significantly less weight across the study, were more active in response to a novel or familiar environment. Isolated rats also acquired nose-poking for a food pellet more rapidly, and showed increased susceptibility to cue-, but not reward-induced reinstatement. Notably, these effects are partially mitigated by a return to group housing, suggesting that they are not necessarily permanent, and that a return to a social setting can quickly reverse any deficits or changes associated with social isolation. This study advances our understanding of altered reward-processing in socially isolated individuals and reiterates the importance of socialisation in the treatment of disorders such as overeating and addiction.
format	article
author	Natalie A. Mastrogiovanni Alice K. Wheeler Kelly J. Clemens
author_facet	Natalie A. Mastrogiovanni Alice K. Wheeler Kelly J. Clemens
author_sort	Natalie A. Mastrogiovanni
title	Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
title_short	Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
title_full	Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
title_fullStr	Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
title_full_unstemmed	Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
title_sort	social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7af1a185de7f429ba2a9b5c316985bf2
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Social isolation enhances cued-reinstatement of sucrose and nicotine seeking, but this is reversed by a return to social housing

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