Structural and energetic effects of A2A adenosine receptor mutations on agonist and antagonist binding.

To predict structural and energetic effects of point mutations on ligand binding is of considerable interest in biochemistry and pharmacology. This is not only useful in connection with site-directed mutagenesis experiments, but could also allow interpretation and prediction of individual responses...

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Bibliographic Details
Main Authors: Henrik Keränen, Hugo Gutiérrez-de-Terán, Johan Åqvist
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
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Online Access:https://doaj.org/article/7af1d254a1b04131aa9e60ba532b2119
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