Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid

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Autores principales:	Jacob W. Vogel, Yasser Iturria-Medina, Olof T. Strandberg, Ruben Smith, Elizabeth Levitis, Alan C. Evans, Oskar Hansson, Alzheimer’s Disease Neuroimaging Initiative, the Swedish BioFinder Study
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7af80602b80f442faa5519b7ab861cc2
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spelling	oai:doaj.org-article:7af80602b80f442faa5519b7ab861cc22021-12-02T14:47:29ZSpread of pathological tau proteins through communicating neurons in human Alzheimer's disease10.1038/s41467-020-15701-22041-1723https://doaj.org/article/7af80602b80f442faa5519b7ab861cc22020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15701-2https://doaj.org/toc/2041-1723The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloidJacob W. VogelYasser Iturria-MedinaOlof T. StrandbergRuben SmithElizabeth LevitisAlan C. EvansOskar HanssonAlzheimer’s Disease Neuroimaging Initiativethe Swedish BioFinder StudyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jacob W. Vogel Yasser Iturria-Medina Olof T. Strandberg Ruben Smith Elizabeth Levitis Alan C. Evans Oskar Hansson Alzheimer’s Disease Neuroimaging Initiative the Swedish BioFinder Study Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
description	The tau protein is theorized to spread transneuronally in Alzheimers disease, though this theory remains unproven in humans. Our simulations of epidemic-like protein spreading across human brain networks support this theory, and suggest the spreading dynamics are modified by β-amyloid
format	article
author	Jacob W. Vogel Yasser Iturria-Medina Olof T. Strandberg Ruben Smith Elizabeth Levitis Alan C. Evans Oskar Hansson Alzheimer’s Disease Neuroimaging Initiative the Swedish BioFinder Study
author_facet	Jacob W. Vogel Yasser Iturria-Medina Olof T. Strandberg Ruben Smith Elizabeth Levitis Alan C. Evans Oskar Hansson Alzheimer’s Disease Neuroimaging Initiative the Swedish BioFinder Study
author_sort	Jacob W. Vogel
title	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_short	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_full	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_fullStr	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_full_unstemmed	Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
title_sort	spread of pathological tau proteins through communicating neurons in human alzheimer's disease
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7af80602b80f442faa5519b7ab861cc2
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Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

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