Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer

Background: Yin Yang 1 (YY1), the multifunctional transcription factor, has recently been assigned biological properties related to human malignancies. YY1 can facilitate both tumor suppression and tumor growth. The conflicting role of YY1 in human malignancies is not yet fully explained. Objective:...

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Autores principales:	Hyunsung Kim, Seongsik Bang, Seungyun Jee, Seongeon Park, Yeseul Kim, Hosub Park, Kiseok Jang, Seung Sam Paik
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	colorectal adenocarcinoma immunohistochemistry prognosis yy1 Pathology RB1-214 Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/7afbecbb285e4f07be9cceaa6b722b9c
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spelling	oai:doaj.org-article:7afbecbb285e4f07be9cceaa6b722b9c2021-12-02T19:23:04ZLoss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer0377-492910.4103/IJPM.IJPM_96_20https://doaj.org/article/7afbecbb285e4f07be9cceaa6b722b9c2021-01-01T00:00:00Zhttp://www.ijpmonline.org/article.asp?issn=0377-4929;year=2021;volume=64;issue=5;spage=78;epage=84;aulast=Kimhttps://doaj.org/toc/0377-4929Background: Yin Yang 1 (YY1), the multifunctional transcription factor, has recently been assigned biological properties related to human malignancies. YY1 can facilitate both tumor suppression and tumor growth. The conflicting role of YY1 in human malignancies is not yet fully explained. Objective: In this study, we determined the clinicopathologic significance and prognostic role of YY1 in stage III colorectal cancer (CRC). Materials and Methods: YY1 expression was evaluated immunohistochemically in tissue microarray from 345 CRCs. YY1 expression was scored by the proportion of tumor cells with nuclear staining into 4 scores (0, none; 1+, ≤10%; 2+, 10 to ≤25%; 3+, >25%). A score of 0 and 1 were considered as loss of expression. Results: Loss of YY1 expression was observed in 49 (14.2%) out of 345 CRCs and was associated with larger tumor size (P = 0.004), tumor deposit (P = 0.008), and higher pathologic tumor (pT) stage (P = 0.004). In stage III group, loss of YY1 expression was associated with larger tumor size (P = 0.027) and tumor deposit (P = 0.011). Kaplan–Meier survival curves revealed no significant difference between patients with YY1 loss and patients with intact YY1 in both cancer-specific survival and recurrence-free survival (P = 0.330 and P = 0.470, respectively). In American Joint Committee on Cancer (AJCC) stage subgroup, loss of YY1 expression was associated with poor recurrence-free survival in AJCC stage III CRC (P = 0.038). Conclusion: Loss of YY1 expression was significantly associated with aggressive phenotypes and poor patient outcome in AJCC stage III CRC.Hyunsung KimSeongsik BangSeungyun JeeSeongeon ParkYeseul KimHosub ParkKiseok JangSeung Sam PaikWolters Kluwer Medknow Publicationsarticlecolorectal adenocarcinomaimmunohistochemistryprognosisyy1PathologyRB1-214MicrobiologyQR1-502ENIndian Journal of Pathology and Microbiology, Vol 64, Iss 5, Pp 78-84 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	colorectal adenocarcinoma immunohistochemistry prognosis yy1 Pathology RB1-214 Microbiology QR1-502
spellingShingle	colorectal adenocarcinoma immunohistochemistry prognosis yy1 Pathology RB1-214 Microbiology QR1-502 Hyunsung Kim Seongsik Bang Seungyun Jee Seongeon Park Yeseul Kim Hosub Park Kiseok Jang Seung Sam Paik Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
description	Background: Yin Yang 1 (YY1), the multifunctional transcription factor, has recently been assigned biological properties related to human malignancies. YY1 can facilitate both tumor suppression and tumor growth. The conflicting role of YY1 in human malignancies is not yet fully explained. Objective: In this study, we determined the clinicopathologic significance and prognostic role of YY1 in stage III colorectal cancer (CRC). Materials and Methods: YY1 expression was evaluated immunohistochemically in tissue microarray from 345 CRCs. YY1 expression was scored by the proportion of tumor cells with nuclear staining into 4 scores (0, none; 1+, ≤10%; 2+, 10 to ≤25%; 3+, >25%). A score of 0 and 1 were considered as loss of expression. Results: Loss of YY1 expression was observed in 49 (14.2%) out of 345 CRCs and was associated with larger tumor size (P = 0.004), tumor deposit (P = 0.008), and higher pathologic tumor (pT) stage (P = 0.004). In stage III group, loss of YY1 expression was associated with larger tumor size (P = 0.027) and tumor deposit (P = 0.011). Kaplan–Meier survival curves revealed no significant difference between patients with YY1 loss and patients with intact YY1 in both cancer-specific survival and recurrence-free survival (P = 0.330 and P = 0.470, respectively). In American Joint Committee on Cancer (AJCC) stage subgroup, loss of YY1 expression was associated with poor recurrence-free survival in AJCC stage III CRC (P = 0.038). Conclusion: Loss of YY1 expression was significantly associated with aggressive phenotypes and poor patient outcome in AJCC stage III CRC.
format	article
author	Hyunsung Kim Seongsik Bang Seungyun Jee Seongeon Park Yeseul Kim Hosub Park Kiseok Jang Seung Sam Paik
author_facet	Hyunsung Kim Seongsik Bang Seungyun Jee Seongeon Park Yeseul Kim Hosub Park Kiseok Jang Seung Sam Paik
author_sort	Hyunsung Kim
title	Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
title_short	Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
title_full	Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
title_fullStr	Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
title_full_unstemmed	Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer
title_sort	loss of yy1 expression predicts unfavorable prognosis in stage iii colorectal cancer
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/7afbecbb285e4f07be9cceaa6b722b9c
work_keys_str_mv	AT hyunsungkim lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT seongsikbang lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT seungyunjee lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT seongeonpark lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT yeseulkim lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT hosubpark lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT kiseokjang lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer AT seungsampaik lossofyy1expressionpredictsunfavorableprognosisinstageiiicolorectalcancer
_version_	1718376686413676544

Loss of YY1 expression predicts unfavorable prognosis in stage III colorectal cancer

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