Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy

The aim of this work was to find out the optimal concentration of gelling agents or their optimal combination in the olive oil environment to stabilise the suspension of chondroitin sulphate. Purified olive oil was structured with rice bran wax or a combination of gelators – soy lecithin and sorbita...

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Autor principal:	Zima J.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	oleogel edible oleogelators lecithin chondroitin sulphate suspension Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/7afce6ca3ec047c98cd655c85364079b
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id	oai:doaj.org-article:7afce6ca3ec047c98cd655c85364079b
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spelling	oai:doaj.org-article:7afce6ca3ec047c98cd655c85364079b2021-12-05T14:11:05ZSuspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy2453-672510.2478/afpuc-2021-0006https://doaj.org/article/7afce6ca3ec047c98cd655c85364079b2021-09-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2021-0006https://doaj.org/toc/2453-6725The aim of this work was to find out the optimal concentration of gelling agents or their optimal combination in the olive oil environment to stabilise the suspension of chondroitin sulphate. Purified olive oil was structured with rice bran wax or a combination of gelators – soy lecithin and sorbitan tristearate. Rice bran wax creates a viscous fluid without a gel structure. The combination of soy lecithin and sorbitan tristearate forms a gel structure from 5 wt.% of the concentration. The optimal ratio of soy lecithin and sorbitan tristearate was found to be 3:2 wt.%. Oleogel was immobile at temperatures below 8°C; on increasing the temperature, it changed to a viscous liquid. The oleogel environment opens new possibilities for creating oral route immunotherapy approaches such as glycoprotein-derived macrophage activating factor-derived immunotherapy.Zima J.Sciendoarticleoleogeledible oleogelatorslecithinchondroitin sulphate suspensionTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 92-93 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	oleogel edible oleogelators lecithin chondroitin sulphate suspension Therapeutics. Pharmacology RM1-950
spellingShingle	oleogel edible oleogelators lecithin chondroitin sulphate suspension Therapeutics. Pharmacology RM1-950 Zima J. Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
description	The aim of this work was to find out the optimal concentration of gelling agents or their optimal combination in the olive oil environment to stabilise the suspension of chondroitin sulphate. Purified olive oil was structured with rice bran wax or a combination of gelators – soy lecithin and sorbitan tristearate. Rice bran wax creates a viscous fluid without a gel structure. The combination of soy lecithin and sorbitan tristearate forms a gel structure from 5 wt.% of the concentration. The optimal ratio of soy lecithin and sorbitan tristearate was found to be 3:2 wt.%. Oleogel was immobile at temperatures below 8°C; on increasing the temperature, it changed to a viscous liquid. The oleogel environment opens new possibilities for creating oral route immunotherapy approaches such as glycoprotein-derived macrophage activating factor-derived immunotherapy.
format	article
author	Zima J.
author_facet	Zima J.
author_sort	Zima J.
title	Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
title_short	Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
title_full	Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
title_fullStr	Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
title_full_unstemmed	Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy
title_sort	suspension of glycosaminoglycans in oleogel environment and application perspective in gcmaf immunotherapy
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/7afce6ca3ec047c98cd655c85364079b
work_keys_str_mv	AT zimaj suspensionofglycosaminoglycansinoleogelenvironmentandapplicationperspectiveingcmafimmunotherapy
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Suspension of Glycosaminoglycans in Oleogel Environment and Application Perspective in GcMAF Immunotherapy

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