Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles

Jonathan Lellouche,1,2 Alexandra Friedman,2 Aharon Gedanken,2 Ehud Banin11Biofilm Research Laboratory, The Mina and Everard Goodman Faculty of Life Sciences, 2Kanbar Laboratory for Nanomaterials, Department of Chemistry, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat...

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Autores principales:	Lellouche J, Friedman A, Gedanken A, Banin E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b002ea7f3754374a375e73e458cd450
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spelling	oai:doaj.org-article:7b002ea7f3754374a375e73e458cd4502021-12-02T07:15:35ZAntibacterial and antibiofilm properties of yttrium fluoride nanoparticles1176-91141178-2013https://doaj.org/article/7b002ea7f3754374a375e73e458cd4502012-11-01T00:00:00Zhttp://www.dovepress.com/antibacterial-and-antibiofilm-properties-of-yttrium-fluoride-nanoparti-a11469https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jonathan Lellouche,1,2 Alexandra Friedman,2 Aharon Gedanken,2 Ehud Banin11Biofilm Research Laboratory, The Mina and Everard Goodman Faculty of Life Sciences, 2Kanbar Laboratory for Nanomaterials, Department of Chemistry, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, IsraelAbstract: Antibiotic resistance has prompted the search for new agents that can inhibit bacterial growth. Moreover, colonization of abiotic surfaces by microorganisms and the formation of biofilms is a major cause of infections associated with medical implants, resulting in prolonged hospitalization periods and patient mortality. In this study we describe a water-based synthesis of yttrium fluoride (YF3) nanoparticles (NPs) using sonochemistry. The sonochemical irradiation of an aqueous solution of yttrium (III) acetate tetrahydrate [Y(Ac)3 &bull; (H2O)4], containing acidic HF as the fluorine ion source, yielded nanocrystalline needle-shaped YF3 particles. The obtained NPs were characterized by scanning electron microscopy and X-ray elemental analysis. NP crystallinity was confirmed by electron and powder X-ray diffractions. YF3 NPs showed antibacterial properties against two common bacterial pathogens (Escherichia coli and Staphylococcus aureus) at a &micro;g/mL range. We were also able to demonstrate that antimicrobial activity was dependent on NP size. In addition, catheters were surface modified with YF3 NPs using a one-step synthesis and coating process. The coating procedure yielded a homogeneous YF3 NP layer on the catheter, as analyzed by scanning electron microscopy and energy dispersive spectroscopy. These YF3 NP-modified catheters were investigated for their ability to restrict bacterial biofilm formation. The YF3 NP-coated catheters were able to significantly reduce bacterial colonization compared to the uncoated surface. Taken together, our results highlight the potential to further develop the concept of utilizing these metal fluoride NPs as novel antimicrobial and antibiofilm agents, taking advantage of their low solubility and providing extended protection.Keywords: yttrium fluoride, nanoparticles, biofilms, antibacterial, catheter, sterile surfacesLellouche JFriedman AGedanken ABanin EDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 5611-5624 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Lellouche J Friedman A Gedanken A Banin E Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
description	Jonathan Lellouche,1,2 Alexandra Friedman,2 Aharon Gedanken,2 Ehud Banin11Biofilm Research Laboratory, The Mina and Everard Goodman Faculty of Life Sciences, 2Kanbar Laboratory for Nanomaterials, Department of Chemistry, Institute for Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan, IsraelAbstract: Antibiotic resistance has prompted the search for new agents that can inhibit bacterial growth. Moreover, colonization of abiotic surfaces by microorganisms and the formation of biofilms is a major cause of infections associated with medical implants, resulting in prolonged hospitalization periods and patient mortality. In this study we describe a water-based synthesis of yttrium fluoride (YF3) nanoparticles (NPs) using sonochemistry. The sonochemical irradiation of an aqueous solution of yttrium (III) acetate tetrahydrate [Y(Ac)3 &bull; (H2O)4], containing acidic HF as the fluorine ion source, yielded nanocrystalline needle-shaped YF3 particles. The obtained NPs were characterized by scanning electron microscopy and X-ray elemental analysis. NP crystallinity was confirmed by electron and powder X-ray diffractions. YF3 NPs showed antibacterial properties against two common bacterial pathogens (Escherichia coli and Staphylococcus aureus) at a &micro;g/mL range. We were also able to demonstrate that antimicrobial activity was dependent on NP size. In addition, catheters were surface modified with YF3 NPs using a one-step synthesis and coating process. The coating procedure yielded a homogeneous YF3 NP layer on the catheter, as analyzed by scanning electron microscopy and energy dispersive spectroscopy. These YF3 NP-modified catheters were investigated for their ability to restrict bacterial biofilm formation. The YF3 NP-coated catheters were able to significantly reduce bacterial colonization compared to the uncoated surface. Taken together, our results highlight the potential to further develop the concept of utilizing these metal fluoride NPs as novel antimicrobial and antibiofilm agents, taking advantage of their low solubility and providing extended protection.Keywords: yttrium fluoride, nanoparticles, biofilms, antibacterial, catheter, sterile surfaces
format	article
author	Lellouche J Friedman A Gedanken A Banin E
author_facet	Lellouche J Friedman A Gedanken A Banin E
author_sort	Lellouche J
title	Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
title_short	Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
title_full	Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
title_fullStr	Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
title_full_unstemmed	Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
title_sort	antibacterial and antibiofilm properties of yttrium fluoride nanoparticles
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7b002ea7f3754374a375e73e458cd450
work_keys_str_mv	AT lellouchej antibacterialandantibiofilmpropertiesofyttriumfluoridenanoparticles AT friedmana antibacterialandantibiofilmpropertiesofyttriumfluoridenanoparticles AT gedankena antibacterialandantibiofilmpropertiesofyttriumfluoridenanoparticles AT banine antibacterialandantibiofilmpropertiesofyttriumfluoridenanoparticles
_version_	1718399522679291904

Antibacterial and antibiofilm properties of yttrium fluoride nanoparticles

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