Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview

The WHO-category Myelodysplastic/Myeloproliferative neoplasms (MDS/MPNs) recognizes a unique group of clonal myeloid malignancies exhibiting overlapping features of myelodysplastic as well as myeloproliferative neoplasms. The group consists of chronic myelomonocytic leukemia (CMML), atypical chronic...

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Autores principales:	Andrea Kuendgen, Annika Kasprzak, Ulrich Germing
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	MDS/MPN overlap syndromes CMML MDS/MPN-RS-T aCML JMML Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/7b0043fe957442b68784655a63523bb0
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spelling	oai:doaj.org-article:7b0043fe957442b68784655a63523bb02021-11-16T06:57:11ZHybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview2234-943X10.3389/fonc.2021.778741https://doaj.org/article/7b0043fe957442b68784655a63523bb02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.778741/fullhttps://doaj.org/toc/2234-943XThe WHO-category Myelodysplastic/Myeloproliferative neoplasms (MDS/MPNs) recognizes a unique group of clonal myeloid malignancies exhibiting overlapping features of myelodysplastic as well as myeloproliferative neoplasms. The group consists of chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia, BCR-ABL1-negative (aCML), juvenile myelomonocytic leukemia (JMML), myelodysplastic/myeloproliferative neoplasm with ringed sideroblasts and thrombocytosis (MDS/MPN-RS-T), and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U). The most frequent entity in this category is CMML, while all other diseases are extremely rare. Thus, only very limited data on the epidemiology of these subgroups exists. An appropriate diagnosis and classification can be challenging since the diagnosis is still largely based on morphologic criteria and myelodysplastic as well as myeloproliferative features can be found in various occurrences. The diseases in this category share several features that are common in this specific WHO-category, but also exhibit specific traits for each disease. This review summarizes published data on epidemiological features and offers a brief overview of the main diagnostic criteria and clinical characteristics of the five MDS/MPN subgroups.Andrea KuendgenAnnika KasprzakUlrich GermingFrontiers Media S.A.articleMDS/MPNoverlap syndromesCMMLMDS/MPN-RS-TaCMLJMMLNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MDS/MPN overlap syndromes CMML MDS/MPN-RS-T aCML JMML Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	MDS/MPN overlap syndromes CMML MDS/MPN-RS-T aCML JMML Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Andrea Kuendgen Annika Kasprzak Ulrich Germing Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
description	The WHO-category Myelodysplastic/Myeloproliferative neoplasms (MDS/MPNs) recognizes a unique group of clonal myeloid malignancies exhibiting overlapping features of myelodysplastic as well as myeloproliferative neoplasms. The group consists of chronic myelomonocytic leukemia (CMML), atypical chronic myeloid leukemia, BCR-ABL1-negative (aCML), juvenile myelomonocytic leukemia (JMML), myelodysplastic/myeloproliferative neoplasm with ringed sideroblasts and thrombocytosis (MDS/MPN-RS-T), and myelodysplastic/myeloproliferative neoplasms, unclassifiable (MDS/MPN-U). The most frequent entity in this category is CMML, while all other diseases are extremely rare. Thus, only very limited data on the epidemiology of these subgroups exists. An appropriate diagnosis and classification can be challenging since the diagnosis is still largely based on morphologic criteria and myelodysplastic as well as myeloproliferative features can be found in various occurrences. The diseases in this category share several features that are common in this specific WHO-category, but also exhibit specific traits for each disease. This review summarizes published data on epidemiological features and offers a brief overview of the main diagnostic criteria and clinical characteristics of the five MDS/MPN subgroups.
format	article
author	Andrea Kuendgen Annika Kasprzak Ulrich Germing
author_facet	Andrea Kuendgen Annika Kasprzak Ulrich Germing
author_sort	Andrea Kuendgen
title	Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
title_short	Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
title_full	Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
title_fullStr	Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
title_full_unstemmed	Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview
title_sort	hybrid or mixed myelodysplastic/myeloproliferative disorders – epidemiological features and overview
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7b0043fe957442b68784655a63523bb0
work_keys_str_mv	AT andreakuendgen hybridormixedmyelodysplasticmyeloproliferativedisordersepidemiologicalfeaturesandoverview AT annikakasprzak hybridormixedmyelodysplasticmyeloproliferativedisordersepidemiologicalfeaturesandoverview AT ulrichgerming hybridormixedmyelodysplasticmyeloproliferativedisordersepidemiologicalfeaturesandoverview
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Hybrid or Mixed Myelodysplastic/Myeloproliferative Disorders – Epidemiological Features and Overview

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