Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China

Background: To explore the differences in clinical manifestations and infection marker determination for early diagnosis of coronavirus disease-2019 (COVID-19) and influenza (A and B).Methods: A hospital-based retrospective cohort study was designed. Patients with COVID-19 and inpatients with influe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yongzhi Li, Huan He, Yuhan Gao, Zejin Ou, Wenqiao He, Caiyun Chen, Jiaqi Fu, Husheng Xiong, Qing Chen
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 influenza retrospective cohort study clinical characteristics ROC curve Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/7b00eaaea34a48c8b59c8f3f14f12bb8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7b00eaaea34a48c8b59c8f3f14f12bb8
record_format	dspace
spelling	oai:doaj.org-article:7b00eaaea34a48c8b59c8f3f14f12bb82021-11-11T06:10:07ZComparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China2296-858X10.3389/fmed.2021.733999https://doaj.org/article/7b00eaaea34a48c8b59c8f3f14f12bb82021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.733999/fullhttps://doaj.org/toc/2296-858XBackground: To explore the differences in clinical manifestations and infection marker determination for early diagnosis of coronavirus disease-2019 (COVID-19) and influenza (A and B).Methods: A hospital-based retrospective cohort study was designed. Patients with COVID-19 and inpatients with influenza at a sentinel surveillance hospital were recruited. Demographic data, medical history, laboratory findings, and radiographic characteristics were summarized and compared between the two groups. The chi-square test or Fisher's exact test was used for categorical variables, and Kruskal–Wallis H-test was used for continuous variables in each group. Receiver operating characteristic curve (ROC) was used to differentiate the intergroup characteristics. The Cox proportional hazards model was used to analyze the predisposing factors.Results: About 23 patients with COVID-19 and 74 patients with influenza were included in this study. Patients with influenza exhibited more symptoms of cough and sputum production than COVID-19 (p < 0.05). CT showed that consolidation and pleural effusion were more common in influenza than COVID-19 (p < 0.05). Subgroup analysis showed that patients with influenza had high values of infection and coagulation function markers, but low values of blood routine and biochemical test markers than patients with COVID-19 (mild or moderate groups) (p < 0.05). In patients with COVID-19, the ROC analysis showed positive predictions of albumin and hematocrit, but negative predictions of C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), and erythrocyte sedimentation rate. Multivariate analysis revealed that influenza might associate with risk of elevated CRP, PCT, and LDH, whereas COVID-19 might associated with high HBDH.Conclusion: Patients with influenza had more obvious clinical symptoms but less common consolidation lesions and pleural effusion than those with COVID-19. These findings suggested that influenza likely presents with stronger inflammatory reactions than COVID-19, which provides some insights into the pathogenesis of these two contagious respiratory illnesses.Yongzhi LiHuan HeYuhan GaoZejin OuWenqiao HeCaiyun ChenJiaqi FuHusheng XiongQing ChenFrontiers Media S.A.articleCOVID-19influenzaretrospective cohort studyclinical characteristicsROC curveMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 influenza retrospective cohort study clinical characteristics ROC curve Medicine (General) R5-920
spellingShingle	COVID-19 influenza retrospective cohort study clinical characteristics ROC curve Medicine (General) R5-920 Yongzhi Li Huan He Yuhan Gao Zejin Ou Wenqiao He Caiyun Chen Jiaqi Fu Husheng Xiong Qing Chen Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China
description	Background: To explore the differences in clinical manifestations and infection marker determination for early diagnosis of coronavirus disease-2019 (COVID-19) and influenza (A and B).Methods: A hospital-based retrospective cohort study was designed. Patients with COVID-19 and inpatients with influenza at a sentinel surveillance hospital were recruited. Demographic data, medical history, laboratory findings, and radiographic characteristics were summarized and compared between the two groups. The chi-square test or Fisher's exact test was used for categorical variables, and Kruskal–Wallis H-test was used for continuous variables in each group. Receiver operating characteristic curve (ROC) was used to differentiate the intergroup characteristics. The Cox proportional hazards model was used to analyze the predisposing factors.Results: About 23 patients with COVID-19 and 74 patients with influenza were included in this study. Patients with influenza exhibited more symptoms of cough and sputum production than COVID-19 (p < 0.05). CT showed that consolidation and pleural effusion were more common in influenza than COVID-19 (p < 0.05). Subgroup analysis showed that patients with influenza had high values of infection and coagulation function markers, but low values of blood routine and biochemical test markers than patients with COVID-19 (mild or moderate groups) (p < 0.05). In patients with COVID-19, the ROC analysis showed positive predictions of albumin and hematocrit, but negative predictions of C-reactive protein (CRP), procalcitonin (PCT), lactate dehydrogenase (LDH), hydroxybutyrate dehydrogenase (HBDH), and erythrocyte sedimentation rate. Multivariate analysis revealed that influenza might associate with risk of elevated CRP, PCT, and LDH, whereas COVID-19 might associated with high HBDH.Conclusion: Patients with influenza had more obvious clinical symptoms but less common consolidation lesions and pleural effusion than those with COVID-19. These findings suggested that influenza likely presents with stronger inflammatory reactions than COVID-19, which provides some insights into the pathogenesis of these two contagious respiratory illnesses.
format	article
author	Yongzhi Li Huan He Yuhan Gao Zejin Ou Wenqiao He Caiyun Chen Jiaqi Fu Husheng Xiong Qing Chen
author_facet	Yongzhi Li Huan He Yuhan Gao Zejin Ou Wenqiao He Caiyun Chen Jiaqi Fu Husheng Xiong Qing Chen
author_sort	Yongzhi Li
title	Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China
title_short	Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China
title_full	Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China
title_fullStr	Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China
title_full_unstemmed	Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China
title_sort	comparison of clinical characteristics for distinguishing covid-19 from influenza during the early stages in guangdong, china
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/7b00eaaea34a48c8b59c8f3f14f12bb8
work_keys_str_mv	AT yongzhili comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT huanhe comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT yuhangao comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT zejinou comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT wenqiaohe comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT caiyunchen comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT jiaqifu comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT hushengxiong comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina AT qingchen comparisonofclinicalcharacteristicsfordistinguishingcovid19frominfluenzaduringtheearlystagesinguangdongchina
_version_	1718439505293213696

Comparison of Clinical Characteristics for Distinguishing COVID-19 From Influenza During the Early Stages in Guangdong, China

Ejemplares similares