Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays

Abstract Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along...

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Autores principales:	Isabelle C. Pinto, Janaína B. Seibert, Luciano S. Pinto, Vagner R. Santos, Rafaela F. de Sousa, Lucas R. D. Sousa, Tatiane R. Amparo, Viviane M. R. dos Santos, Andrea M. do Nascimento, Gustavo Henrique Bianco de Souza, Walisson A. Vasconcellos, Paula M. A. Vieira, Ângela L. Andrade
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b035c0653ae4c5ab4079d55ece6f96e
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spelling	oai:doaj.org-article:7b035c0653ae4c5ab4079d55ece6f96e2021-12-02T13:58:15ZPreparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays10.1038/s41598-020-79257-32045-2322https://doaj.org/article/7b035c0653ae4c5ab4079d55ece6f96e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79257-3https://doaj.org/toc/2045-2322Abstract Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC–QTOF–MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the Mt/M∞ relatively to $$\sqrt t$$ t , at a diffusion coefficient of 1.406 × 10–6 cm2 s−1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.Isabelle C. PintoJanaína B. SeibertLuciano S. PintoVagner R. SantosRafaela F. de SousaLucas R. D. SousaTatiane R. AmparoViviane M. R. dos SantosAndrea M. do NascimentoGustavo Henrique Bianco de SouzaWalisson A. VasconcellosPaula M. A. VieiraÂngela L. AndradeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle C. Pinto Janaína B. Seibert Luciano S. Pinto Vagner R. Santos Rafaela F. de Sousa Lucas R. D. Sousa Tatiane R. Amparo Viviane M. R. dos Santos Andrea M. do Nascimento Gustavo Henrique Bianco de Souza Walisson A. Vasconcellos Paula M. A. Vieira Ângela L. Andrade Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays
description	Abstract Plants may contain beneficial or potentially dangerous substances to humans. This study aimed to prepare and evaluate a new drug delivery system based on a glass-ionomer-Brazilian pepper extract composite, to check for its activity against pathogenic microorganisms of the oral cavity, along with its in vitro biocompatibility. The ethanolic Brazilian pepper extract (BPE), the glass-ionomer cement (GIC) and the composite GIC-BPE were characterized by scanning electron microscopy, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), and thermal analysis. The BPE compounds were identified by UPLC–QTOF–MS/MS. The release profile of flavonoids and the mechanical properties of the GIC-BPE composite were assessed. The flavonoids were released through a linear mechanism governing the diffusion for the first 48 h, as evidenced by the Mt/M∞ relatively to $$\sqrt t$$ t , at a diffusion coefficient of 1.406 × 10–6 cm2 s−1. The ATR-FTIR analysis indicated that a chemical bond between the GIC and BPE components may have occurred, but the compressive strength of GIC-BPE does not differ significantly from that of this glass-ionomer. The GIC-BPE sample revealed an ample bacterial activity at non-cytotoxic concentrations for the human fibroblast MRC-5 cells. These results suggest that the prepared composite may represent an alternative agent for endodontic treatment.
format	article
author	Isabelle C. Pinto Janaína B. Seibert Luciano S. Pinto Vagner R. Santos Rafaela F. de Sousa Lucas R. D. Sousa Tatiane R. Amparo Viviane M. R. dos Santos Andrea M. do Nascimento Gustavo Henrique Bianco de Souza Walisson A. Vasconcellos Paula M. A. Vieira Ângela L. Andrade
author_facet	Isabelle C. Pinto Janaína B. Seibert Luciano S. Pinto Vagner R. Santos Rafaela F. de Sousa Lucas R. D. Sousa Tatiane R. Amparo Viviane M. R. dos Santos Andrea M. do Nascimento Gustavo Henrique Bianco de Souza Walisson A. Vasconcellos Paula M. A. Vieira Ângela L. Andrade
author_sort	Isabelle C. Pinto
title	Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays
title_short	Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays
title_full	Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays
title_fullStr	Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays
title_full_unstemmed	Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays
title_sort	preparation of glass-ionomer cement containing ethanolic brazilian pepper extract (schinus terebinthifolius raddi) fruits: chemical and biological assays
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7b035c0653ae4c5ab4079d55ece6f96e
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Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays

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