Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Abstract High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshiro Tanaka, Tomohisa Nagoshi, Makoto Kawai, Goki Uno, Satoshi Ito, Akira Yoshii, Haruka Kimura, Yasunori Inoue, Kazuo Ogawa, Toshikazu D. Tanaka, Kosuke Minai, Takayuki Ogawa, Michihiro Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b036022dc984811ad1b0f0ea0041491
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7b036022dc984811ad1b0f0ea0041491
record_format	dspace
spelling	oai:doaj.org-article:7b036022dc984811ad1b0f0ea00414912021-12-02T15:18:53ZClose linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis10.1038/s41598-017-02707-y2045-2322https://doaj.org/article/7b036022dc984811ad1b0f0ea00414912017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02707-yhttps://doaj.org/toc/2045-2322Abstract High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise relationship by proposing structural equation models. The study population consisted of 1432 cases with ischemic heart disease who underwent cardiac catheterization. Multiple regression analyses and covariance structure analyses were performed to elucidate the cause-and-effect relationship between UA level and LV ejection fraction (LVEF). A path model exploring the factors contributing to LVEF showed that high UA was a significant cause of reduced LVEF (P = 0.004), independent of other significant factors. The degree of atherosclerosis, as estimated by the number of diseased coronary vessels, was significantly affected by high UA (P = 0.005); and the number of diseased coronary vessels subsequently led to reduced LVEF (P < 0.001). Another path model exploring the factors contributing to UA level showed that LVEF was a significant cause of high UA (P = 0.001), while other risk factors were also independent contributing factors. This study clearly demonstrated that there was a close link between high UA and LV dysfunction, which was represented by possible cause-and-effect relationship.Yoshiro TanakaTomohisa NagoshiMakoto KawaiGoki UnoSatoshi ItoAkira YoshiiHaruka KimuraYasunori InoueKazuo OgawaToshikazu D. TanakaKosuke MinaiTakayuki OgawaMichihiro YoshimuraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshiro Tanaka Tomohisa Nagoshi Makoto Kawai Goki Uno Satoshi Ito Akira Yoshii Haruka Kimura Yasunori Inoue Kazuo Ogawa Toshikazu D. Tanaka Kosuke Minai Takayuki Ogawa Michihiro Yoshimura Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
description	Abstract High serum uric acid (UA) level has been assumed to be a risk factor for left ventricular (LV) dysfunction; however, the precise relationship between these conditions has not been fully examined because many confounding factors are associated with UA level. We herein examined the precise relationship by proposing structural equation models. The study population consisted of 1432 cases with ischemic heart disease who underwent cardiac catheterization. Multiple regression analyses and covariance structure analyses were performed to elucidate the cause-and-effect relationship between UA level and LV ejection fraction (LVEF). A path model exploring the factors contributing to LVEF showed that high UA was a significant cause of reduced LVEF (P = 0.004), independent of other significant factors. The degree of atherosclerosis, as estimated by the number of diseased coronary vessels, was significantly affected by high UA (P = 0.005); and the number of diseased coronary vessels subsequently led to reduced LVEF (P < 0.001). Another path model exploring the factors contributing to UA level showed that LVEF was a significant cause of high UA (P = 0.001), while other risk factors were also independent contributing factors. This study clearly demonstrated that there was a close link between high UA and LV dysfunction, which was represented by possible cause-and-effect relationship.
format	article
author	Yoshiro Tanaka Tomohisa Nagoshi Makoto Kawai Goki Uno Satoshi Ito Akira Yoshii Haruka Kimura Yasunori Inoue Kazuo Ogawa Toshikazu D. Tanaka Kosuke Minai Takayuki Ogawa Michihiro Yoshimura
author_facet	Yoshiro Tanaka Tomohisa Nagoshi Makoto Kawai Goki Uno Satoshi Ito Akira Yoshii Haruka Kimura Yasunori Inoue Kazuo Ogawa Toshikazu D. Tanaka Kosuke Minai Takayuki Ogawa Michihiro Yoshimura
author_sort	Yoshiro Tanaka
title	Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
title_short	Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
title_full	Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
title_fullStr	Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
title_full_unstemmed	Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
title_sort	close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/7b036022dc984811ad1b0f0ea0041491
work_keys_str_mv	AT yoshirotanaka closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT tomohisanagoshi closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT makotokawai closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT gokiuno closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT satoshiito closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT akirayoshii closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT harukakimura closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT yasunoriinoue closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT kazuoogawa closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT toshikazudtanaka closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT kosukeminai closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT takayukiogawa closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis AT michihiroyoshimura closelinkagebetweenserumuricacidandcardiacdysfunctioninpatientswithischemicheartdiseaseaccordingtocovariancestructureanalysis
_version_	1718387454718771200

Close linkage between serum uric acid and cardiac dysfunction in patients with ischemic heart disease according to covariance structure analysis

Ejemplares similares