An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination
In theRussian Federation, Y. pestis NIIEG strain-based live attenuated vaccine is used for immunization against plaque on epidemiological indications, displaying high efficiency. However, individual fluctuations in adaptive immunity after vaccination necessitate conducting a search for genes underly...
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Sankt-Peterburg : NIIÈM imeni Pastera
2019
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oai:doaj.org-article:7b04299a58a8400f86b7755e90b5925b2021-11-22T07:09:52ZAn association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination2220-76192313-739810.15789/2220-7619-2019-2-315-324https://doaj.org/article/7b04299a58a8400f86b7755e90b5925b2019-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/706https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398In theRussian Federation, Y. pestis NIIEG strain-based live attenuated vaccine is used for immunization against plaque on epidemiological indications, displaying high efficiency. However, individual fluctuations in adaptive immunity after vaccination necessitate conducting a search for genes underlying variability of developing immune response. Of note, HLA (Human Leukocyte Antigen) gene polymorphism plays an important role in this process. In our study, we identified HLA class II haplotypes for HLA-DRB1, HLA-DQA1, and HLA-DQB1 in 120 residents of theterritoryofPre-Caspiannatural plague focus, who were immunized against plague. In addition, level of TNFα production correlated with detecting allelic groups HLA-DRB1*04 (р = 0.05) and DRB1*12 (р = 0.01). The data obtained show that HLA class II gene polymorphism can affect the level of cytokine secretion in response to plague immunization. Examining the genes regulating immune factor production will allow to get better insight into the mechanisms underlying immune response variations after vaccination as well as contribute to predicting immunogenicity and efficiency of developing vaccine preparations.O. M. KudryavtsevaS. A. BugorkovaT. N. ShchukovskayaN. I. MikshisA. Yu. GoncharovaS. N. KlyuevaS. A. ShcherbakovaSankt-Peterburg : NIIÈM imeni Pasteraarticlespecific plague prophylaxishla gene polymorphismimmunological efficacyInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 9, Iss 2, Pp 315-324 (2019) |
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DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
specific plague prophylaxis hla gene polymorphism immunological efficacy Infectious and parasitic diseases RC109-216 |
| spellingShingle |
specific plague prophylaxis hla gene polymorphism immunological efficacy Infectious and parasitic diseases RC109-216 O. M. Kudryavtseva S. A. Bugorkova T. N. Shchukovskaya N. I. Mikshis A. Yu. Goncharova S. N. Klyueva S. A. Shcherbakova An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination |
| description |
In theRussian Federation, Y. pestis NIIEG strain-based live attenuated vaccine is used for immunization against plaque on epidemiological indications, displaying high efficiency. However, individual fluctuations in adaptive immunity after vaccination necessitate conducting a search for genes underlying variability of developing immune response. Of note, HLA (Human Leukocyte Antigen) gene polymorphism plays an important role in this process. In our study, we identified HLA class II haplotypes for HLA-DRB1, HLA-DQA1, and HLA-DQB1 in 120 residents of theterritoryofPre-Caspiannatural plague focus, who were immunized against plague. In addition, level of TNFα production correlated with detecting allelic groups HLA-DRB1*04 (р = 0.05) and DRB1*12 (р = 0.01). The data obtained show that HLA class II gene polymorphism can affect the level of cytokine secretion in response to plague immunization. Examining the genes regulating immune factor production will allow to get better insight into the mechanisms underlying immune response variations after vaccination as well as contribute to predicting immunogenicity and efficiency of developing vaccine preparations. |
| format |
article |
| author |
O. M. Kudryavtseva S. A. Bugorkova T. N. Shchukovskaya N. I. Mikshis A. Yu. Goncharova S. N. Klyueva S. A. Shcherbakova |
| author_facet |
O. M. Kudryavtseva S. A. Bugorkova T. N. Shchukovskaya N. I. Mikshis A. Yu. Goncharova S. N. Klyueva S. A. Shcherbakova |
| author_sort |
O. M. Kudryavtseva |
| title |
An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination |
| title_short |
An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination |
| title_full |
An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination |
| title_fullStr |
An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination |
| title_full_unstemmed |
An association between parameters of Th1 and Th2 cell-related functional activity and HLA gene polymorphism in individuals after anti-plague vaccination |
| title_sort |
association between parameters of th1 and th2 cell-related functional activity and hla gene polymorphism in individuals after anti-plague vaccination |
| publisher |
Sankt-Peterburg : NIIÈM imeni Pastera |
| publishDate |
2019 |
| url |
https://doaj.org/article/7b04299a58a8400f86b7755e90b5925b |
| work_keys_str_mv |
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| _version_ |
1718417925481693184 |