Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.

Both Plasmodium falciparum and Anopheles gambiae show great diversity in Africa, in their own genetic makeup and population dynamics. The genetics of the individual mosquito and parasite are known to play a role in determining the outcome of infection in the vector, but whether differences in infect...

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Autores principales:	Caroline Harris, Isabelle Morlais, Thomas S Churcher, Parfait Awono-Ambene, Louis Clement Gouagna, Roch K Dabire, Didier Fontenille, Anna Cohuet
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b042e12084b4328bac55d886289adde
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spelling	oai:doaj.org-article:7b042e12084b4328bac55d886289adde2021-11-18T07:29:14ZPlasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.1932-620310.1371/journal.pone.0030849https://doaj.org/article/7b042e12084b4328bac55d886289adde2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22292059/?tool=EBIhttps://doaj.org/toc/1932-6203Both Plasmodium falciparum and Anopheles gambiae show great diversity in Africa, in their own genetic makeup and population dynamics. The genetics of the individual mosquito and parasite are known to play a role in determining the outcome of infection in the vector, but whether differences in infection phenotype vary between populations remains to be investigated. Here we established two A. gambiae s.s. M molecular form colonies from Cameroon and Burkina Faso, representing a local and a foreign population for each of the geographical sites. Experimental infections of both colonies were conducted in Cameroon and Burkina Faso using local wild P. falciparum, giving a sympatric and allopatric vector-parasite combination in each site. Infection phenotype was determined in terms of oocyst prevalence and intensity for at least nine infections for each vector-parasite combination. Sympatric infections were found to produce 25% fewer oocysts per midgut than allopatric infections, while prevalence was not affected by local/foreign interactions. The reduction in oocyst numbers in sympatric couples may be the result of evolutionary processes where the mosquito populations have locally adapted to their parasite populations. Future research on vector-parasite interactions must take into account the geographic scale of adaptation revealed here by conducting experiments in natural sympatric populations to give epidemiologically meaningful results.Caroline HarrisIsabelle MorlaisThomas S ChurcherParfait Awono-AmbeneLouis Clement GouagnaRoch K DabireDidier FontenilleAnna CohuetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e30849 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline Harris Isabelle Morlais Thomas S Churcher Parfait Awono-Ambene Louis Clement Gouagna Roch K Dabire Didier Fontenille Anna Cohuet Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.
description	Both Plasmodium falciparum and Anopheles gambiae show great diversity in Africa, in their own genetic makeup and population dynamics. The genetics of the individual mosquito and parasite are known to play a role in determining the outcome of infection in the vector, but whether differences in infection phenotype vary between populations remains to be investigated. Here we established two A. gambiae s.s. M molecular form colonies from Cameroon and Burkina Faso, representing a local and a foreign population for each of the geographical sites. Experimental infections of both colonies were conducted in Cameroon and Burkina Faso using local wild P. falciparum, giving a sympatric and allopatric vector-parasite combination in each site. Infection phenotype was determined in terms of oocyst prevalence and intensity for at least nine infections for each vector-parasite combination. Sympatric infections were found to produce 25% fewer oocysts per midgut than allopatric infections, while prevalence was not affected by local/foreign interactions. The reduction in oocyst numbers in sympatric couples may be the result of evolutionary processes where the mosquito populations have locally adapted to their parasite populations. Future research on vector-parasite interactions must take into account the geographic scale of adaptation revealed here by conducting experiments in natural sympatric populations to give epidemiologically meaningful results.
format	article
author	Caroline Harris Isabelle Morlais Thomas S Churcher Parfait Awono-Ambene Louis Clement Gouagna Roch K Dabire Didier Fontenille Anna Cohuet
author_facet	Caroline Harris Isabelle Morlais Thomas S Churcher Parfait Awono-Ambene Louis Clement Gouagna Roch K Dabire Didier Fontenille Anna Cohuet
author_sort	Caroline Harris
title	Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.
title_short	Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.
title_full	Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.
title_fullStr	Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.
title_full_unstemmed	Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.
title_sort	plasmodium falciparum produce lower infection intensities in local versus foreign anopheles gambiae populations.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/7b042e12084b4328bac55d886289adde
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Plasmodium falciparum produce lower infection intensities in local versus foreign Anopheles gambiae populations.

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