Suicide HSVtk gene delivery by neurotensin-polyplex nanoparticles via the bloodstream and GCV Treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice.

Suicide HSVtk gene delivery by neurotensin-polyplex nanoparticles via the bloodstream and GCV Treatment specifically inhibit the growth of human MDA-MB-231 triple negative breast cancer tumors xenografted in athymic mice.

The human breast adenocarcinoma cell line MDA-MB-231 has the triple-negative breast cancer (TNBC) phenotype, which is an aggressive subtype with no specific treatment. MDA-MB-231 cells express neurotensin receptor type 1 (NTSR1), which makes these cells an attractive target of therapeutic genes that...

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Bibliographic Details
Main Authors: Rosa A Castillo-Rodríguez, Martha L Arango-Rodríguez, Lourdes Escobedo, Daniel Hernandez-Baltazar, Anne Gompel, Patricia Forgez, Daniel Martínez-Fong
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/7b0684970a2b4bb6af0f7d32e7be6dbe
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https://doaj.org/article/7b0684970a2b4bb6af0f7d32e7be6dbe

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