Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency

Metformin Inhibits Cyst Formation in a Zebrafish Model of Polycystin-2 Deficiency

Abstract Autosomal dominant polycystic kidney disease (ADPKD) is a common kidney disease caused by mutations in PKD1 or PKD2. Metformin reduces cyst growth in mouse models of PKD1. However, metformin has not been studied in animal models of PKD2, and the cellular mechanism underlying its effectivene...

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Autores principales: Ming-Yang Chang, Tsu-Lin Ma, Cheng-Chieh Hung, Ya-Chung Tian, Yung-Chang Chen, Chih-Wei Yang, Yi-Chuan Cheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/7b073746b7fe4a018b85d35f2d1d0e2b
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