A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program

It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific gen...

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Autores principales: Siobhan Rice, Thomas Jackson, Nicholas T. Crump, Nicholas Fordham, Natalina Elliott, Sorcha O’Byrne, Maria del Mar Lara Fanego, Dilys Addy, Trisevgeni Crabb, Carryl Dryden, Sarah Inglott, Dariusz Ladon, Gary Wright, Jack Bartram, Philip Ancliff, Adam J. Mead, Christina Halsey, Irene Roberts, Thomas A. Milne, Anindita Roy
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f42396
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spelling oai:doaj.org-article:7b0a760f1ba94c9d84a8eed3c5f423962021-11-28T12:33:58ZA human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program10.1038/s41467-021-27270-z2041-1723https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f423962021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27270-zhttps://doaj.org/toc/2041-1723It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific genes are potential infant-ALL drivers.Siobhan RiceThomas JacksonNicholas T. CrumpNicholas FordhamNatalina ElliottSorcha O’ByrneMaria del Mar Lara FanegoDilys AddyTrisevgeni CrabbCarryl DrydenSarah InglottDariusz LadonGary WrightJack BartramPhilip AncliffAdam J. MeadChristina HalseyIrene RobertsThomas A. MilneAnindita RoyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Siobhan Rice
Thomas Jackson
Nicholas T. Crump
Nicholas Fordham
Natalina Elliott
Sorcha O’Byrne
Maria del Mar Lara Fanego
Dilys Addy
Trisevgeni Crabb
Carryl Dryden
Sarah Inglott
Dariusz Ladon
Gary Wright
Jack Bartram
Philip Ancliff
Adam J. Mead
Christina Halsey
Irene Roberts
Thomas A. Milne
Anindita Roy
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
description It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific genes are potential infant-ALL drivers.
format article
author Siobhan Rice
Thomas Jackson
Nicholas T. Crump
Nicholas Fordham
Natalina Elliott
Sorcha O’Byrne
Maria del Mar Lara Fanego
Dilys Addy
Trisevgeni Crabb
Carryl Dryden
Sarah Inglott
Dariusz Ladon
Gary Wright
Jack Bartram
Philip Ancliff
Adam J. Mead
Christina Halsey
Irene Roberts
Thomas A. Milne
Anindita Roy
author_facet Siobhan Rice
Thomas Jackson
Nicholas T. Crump
Nicholas Fordham
Natalina Elliott
Sorcha O’Byrne
Maria del Mar Lara Fanego
Dilys Addy
Trisevgeni Crabb
Carryl Dryden
Sarah Inglott
Dariusz Ladon
Gary Wright
Jack Bartram
Philip Ancliff
Adam J. Mead
Christina Halsey
Irene Roberts
Thomas A. Milne
Anindita Roy
author_sort Siobhan Rice
title A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
title_short A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
title_full A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
title_fullStr A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
title_full_unstemmed A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
title_sort human fetal liver-derived infant mll-af4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f42396
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