A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific gen...
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Nature Portfolio
2021
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oai:doaj.org-article:7b0a760f1ba94c9d84a8eed3c5f423962021-11-28T12:33:58ZA human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program10.1038/s41467-021-27270-z2041-1723https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f423962021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27270-zhttps://doaj.org/toc/2041-1723It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific genes are potential infant-ALL drivers.Siobhan RiceThomas JacksonNicholas T. CrumpNicholas FordhamNatalina ElliottSorcha O’ByrneMaria del Mar Lara FanegoDilys AddyTrisevgeni CrabbCarryl DrydenSarah InglottDariusz LadonGary WrightJack BartramPhilip AncliffAdam J. MeadChristina HalseyIrene RobertsThomas A. MilneAnindita RoyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021) |
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Science Q Siobhan Rice Thomas Jackson Nicholas T. Crump Nicholas Fordham Natalina Elliott Sorcha O’Byrne Maria del Mar Lara Fanego Dilys Addy Trisevgeni Crabb Carryl Dryden Sarah Inglott Dariusz Ladon Gary Wright Jack Bartram Philip Ancliff Adam J. Mead Christina Halsey Irene Roberts Thomas A. Milne Anindita Roy A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
description |
It is unknown why infant acute lymphoblastic leukemia (ALL) produced by MLL rearrangements leads to worse outcomes than childhood ALL. Here the authors develop a CRISPR-Cas9-induced human xenograft model of MLL-AF4 infant-ALL that faithfully replicates the disease and reveals that fetal-specific genes are potential infant-ALL drivers. |
format |
article |
author |
Siobhan Rice Thomas Jackson Nicholas T. Crump Nicholas Fordham Natalina Elliott Sorcha O’Byrne Maria del Mar Lara Fanego Dilys Addy Trisevgeni Crabb Carryl Dryden Sarah Inglott Dariusz Ladon Gary Wright Jack Bartram Philip Ancliff Adam J. Mead Christina Halsey Irene Roberts Thomas A. Milne Anindita Roy |
author_facet |
Siobhan Rice Thomas Jackson Nicholas T. Crump Nicholas Fordham Natalina Elliott Sorcha O’Byrne Maria del Mar Lara Fanego Dilys Addy Trisevgeni Crabb Carryl Dryden Sarah Inglott Dariusz Ladon Gary Wright Jack Bartram Philip Ancliff Adam J. Mead Christina Halsey Irene Roberts Thomas A. Milne Anindita Roy |
author_sort |
Siobhan Rice |
title |
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
title_short |
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
title_full |
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
title_fullStr |
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
title_full_unstemmed |
A human fetal liver-derived infant MLL-AF4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
title_sort |
human fetal liver-derived infant mll-af4 acute lymphoblastic leukemia model reveals a distinct fetal gene expression program |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/7b0a760f1ba94c9d84a8eed3c5f42396 |
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