Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

Gui-Qian Huang,1,* Hao-Ran Cheng,1,* Yue-Min Wu,1 Qian-Qian Cheng,2 Yu-Min Wang,3 Jia-Li Fu,3 Hui-Xin Zhou,3 Zhen Wang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 2School of Mental Health, Wen...

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Autores principales:	Huang GQ, Cheng HR, Wu YM, Cheng QQ, Wang YM, Fu JL, Zhou HX, Wang Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	acute ischemic stroke stroke-associated pneumonia vitamin d. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/7b0ac21dc9e14ebb90844d3789e130ca
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spelling	oai:doaj.org-article:7b0ac21dc9e14ebb90844d3789e130ca2021-12-02T04:31:10ZReduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke1178-1998https://doaj.org/article/7b0ac21dc9e14ebb90844d3789e130ca2019-12-01T00:00:00Zhttps://www.dovepress.com/reduced-vitamin-d-levels-are-associated-with-stroke-associated-pneumon-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Gui-Qian Huang,1,* Hao-Ran Cheng,1,* Yue-Min Wu,1 Qian-Qian Cheng,2 Yu-Min Wang,3 Jia-Li Fu,3 Hui-Xin Zhou,3 Zhen Wang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 2School of Mental Health, Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 3Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen WangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of ChinaTel +86 577-555780166Fax +86 577-55578033Email wangzhen_wenzhou@163.comBackground and aim: Stroke-associated pneumonia (SAP) is a common complication in patients with acute ischemic stroke (AIS). This study explored the potential relationship between serum vitamin D levels and SAP.Methods: This study recruited 863 consecutive AIS patients. In-hospital SAP was defined as a complication that occurred after stroke, during hospitalization, that was confirmed radiographically. Serum vitamin D levels were measured within 24 hrs of admission and the patients were divided into vitamin D sufficient (>50 nmol/L), insufficient (25–50 nmol/L), and deficient (Results: In this study, 102 (11.8%) patients were diagnosed with SAP. Compared to the patients without SAP, patients with SAP had significantly lower vitamin D levels (P = 0.023). The incidence of SAP was significantly higher in patients with vitamin D deficiency than in those with vitamin D insufficiency or sufficiency (21.2% vs 16.2% & 9.5%, P = 0.006). After adjusting for confounders, vitamin D deficiency and insufficiency were independently associated with SAP (OR = 3.034, 95% CI = 1.207–7.625, P = 0.018; OR = 1.921, 95% CI = 1.204–3.066, P = 0.006, respectively). In multiple-adjusted spline regression, vitamin D levels showed a linear association with the risk of SAP (P < 0.001 for linearity).Conclusion: Reduced vitamin D is a potential risk factor of in-hospital SAP, which can help clinicians identify high-risk SAP patients.Keywords: acute ischemic stroke, stroke-associated pneumonia, vitamin DHuang GQCheng HRWu YMCheng QQWang YMFu JLZhou HXWang ZDove Medical Pressarticleacute ischemic strokestroke-associated pneumoniavitamin d.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 2305-2314 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute ischemic stroke stroke-associated pneumonia vitamin d. Geriatrics RC952-954.6
spellingShingle	acute ischemic stroke stroke-associated pneumonia vitamin d. Geriatrics RC952-954.6 Huang GQ Cheng HR Wu YM Cheng QQ Wang YM Fu JL Zhou HX Wang Z Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
description	Gui-Qian Huang,1,* Hao-Ran Cheng,1,* Yue-Min Wu,1 Qian-Qian Cheng,2 Yu-Min Wang,3 Jia-Li Fu,3 Hui-Xin Zhou,3 Zhen Wang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 2School of Mental Health, Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China; 3Department of Laboratory Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhen WangDepartment of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, People’s Republic of ChinaTel +86 577-555780166Fax +86 577-55578033Email wangzhen_wenzhou@163.comBackground and aim: Stroke-associated pneumonia (SAP) is a common complication in patients with acute ischemic stroke (AIS). This study explored the potential relationship between serum vitamin D levels and SAP.Methods: This study recruited 863 consecutive AIS patients. In-hospital SAP was defined as a complication that occurred after stroke, during hospitalization, that was confirmed radiographically. Serum vitamin D levels were measured within 24 hrs of admission and the patients were divided into vitamin D sufficient (>50 nmol/L), insufficient (25–50 nmol/L), and deficient (Results: In this study, 102 (11.8%) patients were diagnosed with SAP. Compared to the patients without SAP, patients with SAP had significantly lower vitamin D levels (P = 0.023). The incidence of SAP was significantly higher in patients with vitamin D deficiency than in those with vitamin D insufficiency or sufficiency (21.2% vs 16.2% & 9.5%, P = 0.006). After adjusting for confounders, vitamin D deficiency and insufficiency were independently associated with SAP (OR = 3.034, 95% CI = 1.207–7.625, P = 0.018; OR = 1.921, 95% CI = 1.204–3.066, P = 0.006, respectively). In multiple-adjusted spline regression, vitamin D levels showed a linear association with the risk of SAP (P < 0.001 for linearity).Conclusion: Reduced vitamin D is a potential risk factor of in-hospital SAP, which can help clinicians identify high-risk SAP patients.Keywords: acute ischemic stroke, stroke-associated pneumonia, vitamin D
format	article
author	Huang GQ Cheng HR Wu YM Cheng QQ Wang YM Fu JL Zhou HX Wang Z
author_facet	Huang GQ Cheng HR Wu YM Cheng QQ Wang YM Fu JL Zhou HX Wang Z
author_sort	Huang GQ
title	Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
title_short	Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
title_full	Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
title_fullStr	Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
title_full_unstemmed	Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke
title_sort	reduced vitamin d levels are associated with stroke-associated pneumonia in patients with acute ischemic stroke
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7b0ac21dc9e14ebb90844d3789e130ca
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Reduced Vitamin D Levels are Associated with Stroke-Associated Pneumonia in Patients with Acute Ischemic Stroke

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