Transmission of tauopathy strains is independent of their isoform composition

Although normal human brains express 6 tau isoforms in equal ratio with 3 or 4 microtubule-binding repeat domains (3R and 4R), tau inclusions from different human tauopathy brains, now considered as different strains, have distinct isoform compositions and strain properties and the relationship betw...

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Autores principales:	Zhuohao He, Jennifer D. McBride, Hong Xu, Lakshmi Changolkar, Soo-jung Kim, Bin Zhang, Sneha Narasimhan, Garrett S. Gibbons, Jing L. Guo, Michael Kozak, Gerard D. Schellenberg, John Q. Trojanowski, Virginia M. -Y. Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b0b51a6f2f141829341f5519d046c54
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spelling	oai:doaj.org-article:7b0b51a6f2f141829341f5519d046c542021-12-02T14:42:47ZTransmission of tauopathy strains is independent of their isoform composition10.1038/s41467-019-13787-x2041-1723https://doaj.org/article/7b0b51a6f2f141829341f5519d046c542020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13787-xhttps://doaj.org/toc/2041-1723Although normal human brains express 6 tau isoforms in equal ratio with 3 or 4 microtubule-binding repeat domains (3R and 4R), tau inclusions from different human tauopathy brains, now considered as different strains, have distinct isoform compositions and strain properties and the relationship between these two parts is unclear. Here the authors generate a new transgenic mouse line expressing 6 human tau isoforms with equal 3R and 4R ratios, recapitulate distinct human tau strains in mouse brains with similar isoform compositions and cell type specificities, and further show the strain transmission pattern is independent of its isoform composition.Zhuohao HeJennifer D. McBrideHong XuLakshmi ChangolkarSoo-jung KimBin ZhangSneha NarasimhanGarrett S. GibbonsJing L. GuoMichael KozakGerard D. SchellenbergJohn Q. TrojanowskiVirginia M. -Y. LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhuohao He Jennifer D. McBride Hong Xu Lakshmi Changolkar Soo-jung Kim Bin Zhang Sneha Narasimhan Garrett S. Gibbons Jing L. Guo Michael Kozak Gerard D. Schellenberg John Q. Trojanowski Virginia M. -Y. Lee Transmission of tauopathy strains is independent of their isoform composition
description	Although normal human brains express 6 tau isoforms in equal ratio with 3 or 4 microtubule-binding repeat domains (3R and 4R), tau inclusions from different human tauopathy brains, now considered as different strains, have distinct isoform compositions and strain properties and the relationship between these two parts is unclear. Here the authors generate a new transgenic mouse line expressing 6 human tau isoforms with equal 3R and 4R ratios, recapitulate distinct human tau strains in mouse brains with similar isoform compositions and cell type specificities, and further show the strain transmission pattern is independent of its isoform composition.
format	article
author	Zhuohao He Jennifer D. McBride Hong Xu Lakshmi Changolkar Soo-jung Kim Bin Zhang Sneha Narasimhan Garrett S. Gibbons Jing L. Guo Michael Kozak Gerard D. Schellenberg John Q. Trojanowski Virginia M. -Y. Lee
author_facet	Zhuohao He Jennifer D. McBride Hong Xu Lakshmi Changolkar Soo-jung Kim Bin Zhang Sneha Narasimhan Garrett S. Gibbons Jing L. Guo Michael Kozak Gerard D. Schellenberg John Q. Trojanowski Virginia M. -Y. Lee
author_sort	Zhuohao He
title	Transmission of tauopathy strains is independent of their isoform composition
title_short	Transmission of tauopathy strains is independent of their isoform composition
title_full	Transmission of tauopathy strains is independent of their isoform composition
title_fullStr	Transmission of tauopathy strains is independent of their isoform composition
title_full_unstemmed	Transmission of tauopathy strains is independent of their isoform composition
title_sort	transmission of tauopathy strains is independent of their isoform composition
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7b0b51a6f2f141829341f5519d046c54
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_version_	1718389578233020416

Transmission of tauopathy strains is independent of their isoform composition

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