Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy

Abstract Radiotherapy (RT) is one of the main treatment strategies of breast cancer. It is challenging to design RT plans that can completely cover the target area while protecting organs at risk (OAR). The Plan-IQ feasibility tool can estimate the best sparing dose of OAR before optimizing the Plan...

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Autores principales:	Kunzhi Chen, Zhuangzhuang Zheng, Lijuan Ding, Na Tao, Libo Wang, Wenming Xia, Huidong Wang, Xin Jiang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7b0d02e4a5334fc8ae732df16c47e20d
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spelling	oai:doaj.org-article:7b0d02e4a5334fc8ae732df16c47e20d2021-11-14T12:22:50ZSystematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy10.1038/s41598-021-01305-32045-2322https://doaj.org/article/7b0d02e4a5334fc8ae732df16c47e20d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01305-3https://doaj.org/toc/2045-2322Abstract Radiotherapy (RT) is one of the main treatment strategies of breast cancer. It is challenging to design RT plans that can completely cover the target area while protecting organs at risk (OAR). The Plan-IQ feasibility tool can estimate the best sparing dose of OAR before optimizing the Plan. A systematic quantitative evaluation of the quality change of intensity-modulated radiation therapy (IMRT) using the Plan-IQ feasibility tool was performed for modified radical mastectomy in this study. We selected 50 patients with breast cancer treated with IMRT. All patients received the same dose in the planning target volume (PTV). The plans are categorized into two groups, with each patient having one plan in each group: the clinically accepted normal plan group (NP group) and the repeat plan group (RP group). An automated planning strategy was generated using a Plan-IQ feasibility dose volume histogram (FDVH) in RP group. These plans were assessed according to the dosimetry parameters. A detailed scoring strategy was based on the RTOG9804 report and 2018 National Comprehensive Cancer Network guidelines, combined with clinical experience. PTV coverage in both groups was achieved at 100% of the prescribed dose. Except for the thyroid coverage, the dose limit of organs at risk (OAR) in RP group was significantly better than that in NP group. In the scoring analysis, the total scores of RP group decreased compared to that of NP group (P < 0.05), and the individual scores of PTV and OAR significantly changed. PTV scores in RP group decreased (P < 0.01); however, OAR scores improved (P < 0.01). The Plan-IQ FDVH was useful for evaluating a class solution for IMRT planning. Plan-IQ can automatically help physicians design the best OAR protection plan, which sacrifices part of PTV, but still meets clinical requirements.Kunzhi ChenZhuangzhuang ZhengLijuan DingNa TaoLibo WangWenming XiaHuidong WangXin JiangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kunzhi Chen Zhuangzhuang Zheng Lijuan Ding Na Tao Libo Wang Wenming Xia Huidong Wang Xin Jiang Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy
description	Abstract Radiotherapy (RT) is one of the main treatment strategies of breast cancer. It is challenging to design RT plans that can completely cover the target area while protecting organs at risk (OAR). The Plan-IQ feasibility tool can estimate the best sparing dose of OAR before optimizing the Plan. A systematic quantitative evaluation of the quality change of intensity-modulated radiation therapy (IMRT) using the Plan-IQ feasibility tool was performed for modified radical mastectomy in this study. We selected 50 patients with breast cancer treated with IMRT. All patients received the same dose in the planning target volume (PTV). The plans are categorized into two groups, with each patient having one plan in each group: the clinically accepted normal plan group (NP group) and the repeat plan group (RP group). An automated planning strategy was generated using a Plan-IQ feasibility dose volume histogram (FDVH) in RP group. These plans were assessed according to the dosimetry parameters. A detailed scoring strategy was based on the RTOG9804 report and 2018 National Comprehensive Cancer Network guidelines, combined with clinical experience. PTV coverage in both groups was achieved at 100% of the prescribed dose. Except for the thyroid coverage, the dose limit of organs at risk (OAR) in RP group was significantly better than that in NP group. In the scoring analysis, the total scores of RP group decreased compared to that of NP group (P < 0.05), and the individual scores of PTV and OAR significantly changed. PTV scores in RP group decreased (P < 0.01); however, OAR scores improved (P < 0.01). The Plan-IQ FDVH was useful for evaluating a class solution for IMRT planning. Plan-IQ can automatically help physicians design the best OAR protection plan, which sacrifices part of PTV, but still meets clinical requirements.
format	article
author	Kunzhi Chen Zhuangzhuang Zheng Lijuan Ding Na Tao Libo Wang Wenming Xia Huidong Wang Xin Jiang
author_facet	Kunzhi Chen Zhuangzhuang Zheng Lijuan Ding Na Tao Libo Wang Wenming Xia Huidong Wang Xin Jiang
author_sort	Kunzhi Chen
title	Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy
title_short	Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy
title_full	Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy
title_fullStr	Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy
title_full_unstemmed	Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy
title_sort	systematic quantitative evaluation of plan-iq for intensity-modulated radiation therapy after modified radical mastectomy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7b0d02e4a5334fc8ae732df16c47e20d
work_keys_str_mv	AT kunzhichen systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT zhuangzhuangzheng systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT lijuanding systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT natao systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT libowang systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT wenmingxia systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT huidongwang systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy AT xinjiang systematicquantitativeevaluationofplaniqforintensitymodulatedradiationtherapyaftermodifiedradicalmastectomy
_version_	1718429236200472576

Systematic quantitative evaluation of Plan-IQ for intensity-modulated radiation therapy after modified radical mastectomy

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